Medulloblastoma is the most common malignant paediatric brain tumour, with~ 30%
mediated by Sonic hedgehog signalling. Vismodegib-mediated inhibition of the Sonic …

The blood–brain barrier (BBB) is a selectively permeable membrane that separates the
bloodstream from the brain. While useful for protecting neural tissue from harmful …

Photodynamic therapy (PDT) is a promising add-on therapy to the current standard of care
for patients with glioblastoma (GBM). The traditional explanation of the anti-cancer PDT …

The blood–brain barrier (BBB) limits the delivery of majority of cancer drugs and thereby
complicates brain tumor treatment. The nasal-brain-lymphatic system is discussed as a …

Glioblastomas (GBM) are considered one of the most aggressive tumors of the central
nervous system. The standard treatment for GBM-diagnosed patients implies surgery …

The blood-brain barrier (BBB) poses a serious impediment to the delivery of effective
therapies to the central nervous system (CNS). Over time, various model systems have been …

Alzheimer's disease (AD) is a progressive neurological disorder that primarily impacts
cognitive function. Currently there are no disease-modifying treatments to stop or slow its …

The blood-brain barrier (BBB) has a significant contribution to the protection of the central
nervous system (CNS). However, it also limits the brain drug delivery and thereby …

Advanced optical imaging provides a powerful tool for the structural and functional analysis
of tissues with high resolution and contrast, but the imaging performance decreases as light …

Neurogenesis is a key mechanism of brain development and plasticity, which is impaired in
chronic neurodegeneration, including Parkinson's disease. The accumulation of aberrant α …