Numerous cellular processes are controlled by the proteasome, a multicatalytic protease in
the cytosol and nucleus of all eukaryotic cells, through regulated protein degradation. The …

Involving addition of chemical groups or protein units to specific residues of the target
protein, post-translational modifications (PTMs) alter the charge, hydrophobicity, and …

The proteasome, the primary protease for ubiquitin-dependent proteolysis in eukaryotes, is
usually found as a mixture of 30S, 26S, and 20S complexes. These complexes have …

For years, proteasomal degradation was predominantly attributed to the ubiquitin-26S
proteasome pathway. However, it is now evident that the core 20S proteasome can …

Four proteasome subtypes are commonly present in mammalian tissues: standard
proteasomes, which contain the standard catalytic subunits β1, β2 and β5; …

Redox imbalance and oxidative stress have emerged as generative causes of the structural
and functional degradation of red blood cells (RBC) that happens during their hypothermic …

The concept of oxidative distress had arisen from the assessment of cellular response to
high concentrations of reactive species that result from an imbalance between oxidants and …

Abstract Large multifunctional peptidase 7 (LMP7/β5i/PSMB8) is a proteolytic subunit of the
immunoproteasome, which is predominantly expressed in normal and malignant …

The theory that aging is driven by the damage produced by reactive oxygen species (ROS)
derived from oxidative metabolism dominated geroscience studies during the second half of …

The immunoproteasome is a specialized form of proteasome equipped with modified
catalytic subunits that was initially discovered to play a pivotal role in MHC class I antigen …