Microbubbles for human diagnosis and therapy

L Fournier, T de La Taille, C Chauvierre - Biomaterials, 2023 - Elsevier
Microbubbles (MBs) were observed for the first time in vivo as a curious consequence of
quick saline injection during ultrasound (US) imaging of the aortic root, more than 50 years …

Targeting of microbubbles: contrast agents for ultrasound molecular imaging

S Wang, JA Hossack, AL Klibanov - Journal of drug targeting, 2018 - Taylor & Francis
For contrast ultrasound imaging, the most efficient contrast agents comprise highly
compressible gas-filled microbubbles. These micrometer-sized particles are typically filled …

Molecular ultrasound imaging

G Köse, M Darguzyte, F Kiessling - Nanomaterials, 2020 - mdpi.com
In the last decade, molecular ultrasound imaging has been rapidly progressing. It has
proven promising to diagnose angiogenesis, inflammation, and thrombosis, and many …

PBCA-based polymeric microbubbles for molecular imaging and drug delivery

P Koczera, L Appold, Y Shi, M Liu, A Dasgupta… - Journal of controlled …, 2017 - Elsevier
Microbubbles (MB) are routinely used as contrast agents for ultrasound (US) imaging. We
describe different types of targeted and drug-loaded poly (n-butyl cyanoacrylate)(PBCA) MB …

Functionalized polymer microbubbles as new molecular ultrasound contrast agent to target P-selectin in thrombus

B Li, R Aid-Launais, MN Labour, A Zenych, M Juenet… - Biomaterials, 2019 - Elsevier
Thrombotic diseases rarely cause symptoms until advanced stage and sudden death. Thus,
early detection of thrombus by a widely spread imaging modality can improve the prognosis …

Aminolysis-mediated single-step surface functionalization of poly (butyl cyanoacrylate) microbubbles for ultrasound molecular imaging

J Chen, B Wang, A Dasgupta, C Porte… - Journal of …, 2024 - Springer
Molecular ultrasound imaging with actively targeted microbubbles (MB) proved promising in
preclinical studies but its clinical translation is limited. To achieve this, it is essential that the …

Ultrasound technology for molecular imaging: from contrast agents to multimodal imaging

Y Li, Y Chen, M Du, ZY Chen - ACS Biomaterials Science & …, 2018 - ACS Publications
Ultrasound (US) takes advantage of ultrasound contrast agents (UCAs) to further increase
the sensitivity and specificity of monitoring at the cellular level, which has had a …

Accelerated clearance of ultrasound contrast agents containing polyethylene glycol is associated with the generation of anti-polyethylene glycol antibodies

SM Fix, AG Nyankima, MD McSweeney… - Ultrasound in medicine …, 2018 - Elsevier
Emerging evidence suggests that the immune system can recognize polyethylene glycol
(PEG), leading to the accelerated blood clearance (ABC) of PEGylated particles. Our aim …

Systematic imaging in medicine: a comprehensive review

K Zhang, Y Sun, S Wu, M Zhou, X Zhang… - European Journal of …, 2021 - Springer
Systematic imaging can be broadly defined as the systematic identification and
characterization of biological processes at multiple scales and levels. In contrast to …

Toward Ultrasound Molecular Imaging of Endothelial Dysfunction in Diabetes: Targets, Strategies, and Challenges

J Liu, C Wang, S Qiu, W Sun, G Yang… - ACS Applied Bio …, 2024 - ACS Publications
Diabetes vasculopathy is a significant complication of diabetes mellitus (DM), and early
identification and timely intervention can effectively slow the progression. Accumulating …