During the last two decades, an increasing number of reports have pointed out that the
immunogenicity of polyethylene glycol (PEG) may trigger accelerated blood clearance …

Nanoparticle immunogenicity and antigenicity have been under investigation for many
years. During the past decade, significant progress has been made in understanding what …

Nanotherapeutics have been investigated for years, but only modest survival benefits were
observed clinic. This is partially attributed to the short and rapid elimination of nanodrug after …

A novel “collaborative assembly” approach was reported for the synthesis of an siRNA
delivery system via a combination of an electrostatically driven physical assembly and a …

Although PEGylated liposome-based drug delivery systems hold great promising
applications for cancer therapy due to their prolonged blood circulation time, PEGylation …

Multifunctional nanoparticles (NPs), composed of organic and inorganic materials, have
been explored as promising drug-delivery vehicles for cancer diagnosis and therapy. The …

Despite intensive research efforts and development of numerous new anticancer drugs and
treatment strategies over the past decades, there has been only very limited improvement in …

Polyethylene glycol (PEG) is a versatile polymer that is used in numerous pharmaceutical
applications like the food industry, a wide range of disinfectants, cosmetics, and many …

PEGylation has successfully improved the pharmacological properties of therapeutic
proteins. However, polyethylene glycol (PEG) has been burdened by immunogenicity that …

siRNA technology presents a helpful means of gene silencing in mammalian cells.
Advancement in the field includes enhanced attentiveness in the characterization of target …