In the last decade, single-cell RNA sequencing routinely performed on large numbers of
single cells has greatly advanced our understanding of the underlying heterogeneity of …

Cleavage under targets and tagmentation (CUT&Tag) is an antibody-directed in situ
chromatin profiling strategy that is rapidly replacing immune precipitation-based methods …

Chromatin states are functionally defined by a complex combination of histone
modifications, transcription factor binding, DNA accessibility and other factors. Current …

Regulation of chromatin states involves the dynamic interplay between different histone
modifications to control gene expression. Recent advances have enabled mapping of …

Chromatin accessibility is a hallmark of active regulatory regions and is functionally linked to
transcriptional networks and cell identity. However, the molecular mechanisms and networks …

Gene expression programs result from the collective activity of numerous regulatory factors.
Studying their cooperative mode of action is imperative to understand gene regulation, but …

Cell-state density characterizes the distribution of cells along phenotypic landscapes and is
crucial for unraveling the mechanisms that drive diverse biological processes. Here, we …

Sculpting the epigenome with a combination of histone modifications and transcription factor
occupancy determines gene transcription and cell fate specification. Here, we first develop …

As the field of single-cell transcriptomics matures, research is shifting focus from
phenomenological descriptions of cellular phenotypes to a mechanistic understanding of the …

Microglia, the major population of brain‐resident macrophages, are now recognized as a
heterogeneous population comprising several cell subtypes with different (so far mostly …