Schizophrenia is a heterogeneous psychiatric disorder that is poorly treated with current
therapies. In this brief review, we provide an update regarding the use of animal models to …

Attention-deficit/hyperactivity disorder (ADHD) is a highly prevalent neurodevelopmental
disorder resulting from the interaction between genetic and environmental risk factors. It is …

Schizophrenia is a major psychiatric disorder that afflicts about 1% of the world's population,
falling into the top 10 medical disorders causing disability. Existing therapeutic strategies …

Schizophrenia is a psychiatric disorder characterized by hallucinations, anhedonia,
disordered thinking, and cognitive impairments. Both genetic and environmental factors …

Objectives: Several schizophrenia brain regions exhibit decreased dysbindin. Dysbindin
modulates copper transport crucial for myelination, monoamine metabolism and cellular …

Mice lacking a functional Biogenesis of Lysosome-related Organelles Complex 1 (BLOC-1),
such as those of the pallid line, display cognitive and behavioural impairments reminiscent …

Given the detection of aggregated deposits in chronic mental diseases (CMD), the
disturbance of proteostasis in those diseases is receiving increasing attention. The study of …

Alongside positive and negative symptomatology, deficits in working memory, attention,
selective learning processes, and executive function have been widely documented in …

Dysbindin and DISC1 are schizophrenia susceptibility factors playing roles in neuronal
development. Here we show that the physical interaction between dysbindin and DISC1 is …

The presence and severity of cognitive symptoms, including working memory, executive
dysfunction and attentional impairment, contributes materially to functional impairment in …