The global adoption of artemisinin-based combination therapies (ACTs) in the early 2000s
heralded a new era in effectively treating drug-resistant Plasmodium falciparum malaria …

Cryo-electron microscopy (cryo-EM) of non-crystalline single particles is a biophysical
technique that can be used to determine the structure of biological macromolecules and …

With the advent of structural biology in the drug discovery process, medicinal chemists
gained the opportunity to use detailed structural information in order to progress screening …

Highlights•Mutant K13-mediated artemisinin resistance involves reduced hemoglobin
endocytosis.•Artemisinin partial resistance has emerged in Africa.•Novel PfCRT mutations …

Abstract High-grade gliomas (HGGs), including glioblastoma and diffuse intrinsic pontine
glioma, are amongst the most fatal brain tumors. These tumors are associated with a dismal …

Mechanisms of action (MoAs) have been elusive for most antimalarial drugs in clinical use.
Decreasing responsiveness to antimalarial treatments stresses the need for a better …

A widespread strategy employed by pathogens to establish infection is to inhibit host-cell
protein synthesis. Legionella pneumophila, an intracellular bacterial pathogen and the …

Natural products serve as chemical blueprints for most antibiotics in clinical use. The
evolutionary process by which these molecules arise is inherently accompanied by the co …

Emergence and spread of resistance in Plasmodium falciparum to the frontline treatment
artemisinin-based combination therapies (ACTs) in the epicenter of multidrug resistance of …

Artemisinin-based combination therapies (ACTs) have become the mainstay for malaria
treatment in almost all malaria endemic settings. Artemisinin derivatives are highly potent …