Sepsis is a life-threatening clinical syndrome caused by infection. Its pathogenesis is
complex and entails coagulation dysfunction, inflammation, and immune disorders …

Idiopathic pulmonary fibrosis (IPF) is a prototype of lethal, chronic, progressive interstitial
lung disease of unknown etiology. Over the past decade, macrophage has been recognized …

Allergic asthma is associated with airway inflammation and airway hyperresponsiveness.
Macrophage polarization has been shown to have a profound impact on asthma …

Our understanding of the functions of cardiac fibroblasts has moved beyond their roles in
heart structure and extracellular matrix generation and now includes their contributions to …

Cardiac scars, often dubbed 'dead tissue', are very much alive, with heterocellular activity
contributing to the maintenance of structural and mechanical integrity following heart injury …

Lung macrophages link innate and adaptive immune responses during allergic airway
inflammatory responses. Alveolar macrophages (AMs) and interstitial macrophages are two …

The systemic and organ-specific human fibrotic disorders collectively represent one of the
most serious health problems world-wide causing a large proportion of the total world …

In contrast to mammals, adult zebrafish have a high capacity to regenerate damaged or lost
myocardium through proliferation of cardiomyocytes spared from damage. The epicardial …

Fibrosis is a general term encompassing a plethora of pathologies that span all systems and
is marked by increased deposition of collagen. Injury of variable etiology gives rise to …

Elevated interleukin-4 (IL-4) levels are associated with cardiac fibrosis in hypertension and
heart failure in both patients and experimental animals. We hypothesized that chronically …