The gastrointestinal tract has the important task of absorbing nutrients, a complex process
that requires an intact barrier allowing the passage of nutrients but that simultaneously …

Although Escherichia coli can be an innocuous resident of the gastrointestinal tract, it also
has the pathogenic capacity to cause significant diarrheal and extraintestinal diseases …

Shigella is a major cause of bacillary dysentery world-wide. It is divided into four species,
named S. flexneri, S. sonnei, S. dysenteriae, and S. boydii, which are distinct genomically …

Transforming growth factor β-activated kinase 1 (TAK1 or MAP3K7) is a key signaling
component of nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK) …

Enteric Escherichia coli (E. coli) are both natural flora of humans and important pathogens
causing significant morbidity and mortality worldwide. Traditionally enteric E. coli have been …

Salmonella enterica serovars cause severe disease in humans, such as gastroenteritis and
typhoid fever. The bacteria are able to invade and replicate within host cells, including …

The nuclear factor-κB (NF-κB) family of transcription factors plays a central part in the host
response to infection by microbial pathogens, by orchestrating the innate and acquired host …

The tumour necrosis factor (TNF) family is crucial for immune homeostasis, cell death and
inflammation. These cytokines are recognized by members of the TNF receptor (TNFR) …

The human pathogens enteropathogenic and enterohemorrhagic Escherichia coli (EPEC
and EHEC) share a unique mechanism of colonization that results from the concerted action …

Cell death signalling pathways contribute to tissue homeostasis and provide innate
protection from infection. Adaptor proteins such as receptor-interacting serine/threonine …