Disseminated intravascular coagulation (DIC) is an acquired clinicobiological syndrome
characterized by widespread activation of coagulation leading to fibrin deposition in the …

Sepsis represents the host's systemic inflammatory response to a severe infection. It causes
substantial human morbidity resulting in hundreds of thousands of deaths each year …

The notion of blood coagulation dates back to the ancient Greek civilization. However, the
emergence of innovative scientific discoveries that started in the seventeenth century …

The fibrinolytic system includes a broad spectrum of proteolytic enzymes with physiological
and pathophysiological functions in several processes, such as haemostatic balance, tissue …

Recently, a new inhibitor of fibrinolysis was described, which downregulated fibrinolysis
after it was activated by thrombin, and was therefore named TAFI (thrombin-activatable …

Hyperfibrinolysis is thought to contribute to bleeding associated with advanced cirrhosis.
Thrombin activatable fibrinolysis inhibitor (TAFI) is a plasma precursor of a …

Coagulation abnormalities, ranging from a simple fall in platelet count to full-blown
disseminated intravascular coagulation, are a common occurrence in critically ill patients …

Recently, a new inhibitor of fibrinolysis was described. This inhibitor downregulated
fibrinolysis after it was activated by thrombin, and was therefore named TAFI (thrombin …

The coagulation and fibrinolytic systems safeguard the patency of the vasculature and
surrounding tissue. Cross regulation of coagulation and fibrinolysis plays an important role …

Although microvascular dysfunction (MVD) has been well characterized in individual organs
as different disease entities, clinical evidence is mounting in support of an underlying …