Decades of research have established atherosclerosis as an inflammatory disease. Only
recently though, clinical trials provided proof-of-concept evidence for the efficacy of anti …

Chemotactic cytokines—chemokines—control immune cell migration in the process of
initiation and resolution of inflammatory conditions as part of the body's defense system …

CCR7, collaborated with its ligands CCL19 and CCL21, controls extensive migratory events
in the immune system. CCR7-bearing dendritic cells can swarm into T-cell zones in lymph …

Autologous Stem Cell Transplant (ASCT) is increasingly used to treat hematological
malignancies. A key requisite for ASCT is mobilization of hematopoietic stem cells into …

Class AG protein‐coupled receptors (GPCRs) continue to garner interest for their essential
roles in cell signalling and their importance as drug targets. Although numerous drugs in the …

CXCR4 has been a target of interest in drug discovery for numerous years. However, so far,
most if not all studies focused on finding antagonists of CXCR4 function. Recent studies …

Abstract Background and Purpose Glucagon‐like peptide‐2 (GLP‐2) is secreted
postprandially by enteroendocrine L‐cells and stimulates growth of the gut and bone. One …

G protein-coupled receptors (GPCRs) are of outstanding pharmacological interest as they
are abundant in cell membranes where they perform diverse functions that are closely …

Embryonic ethanol exposure in zebrafish and rats, while stimulating hypothalamic
hypocretin/orexin (Hcrt) neurons along with alcohol consumption and related behaviors …

Drug Discovery is an active research area that demands great investments and generates
low returns due to its inherent complexity and great costs. To identify potential therapeutic …