For centuries, people believed that bats possessed sinister powers. Bats are thought to be
ancestral hosts to many deadly viruses affecting humans including Ebola, rabies, and most …

Abstract Matrix metalloproteinases (MMPs), A Disintegrin and Metalloproteinase (ADAM)
and A Disintegrin and Metalloproteinase with Thrombospondin Motif (ADAMTS) are zinc …

Introduction 3. Regulation and Function of MMPs 3.1. Regulation of MMP synthesis 3.2.
MMP structure and function studies 4. MMPs in health and disease 4.1. Skeletal …

Chondrocytes are the single cellular component of hyaline cartilage. Under physiologic
conditions, they show steady-state equilibrium between anabolic and catabolic activities that …

Fourier transform infrared (FT-IR) imaging and microspectroscopy have been extensively
applied to the analyses of tissues in health and disease. Spatially resolved mid-IR data has …

A number of factors including inflammation and oxidative stress are believed to play a role in
the development of chronic joint diseases. Green tea has become a popular drink and is …

Objective Aberrant posttranscriptional regulation of matrix metalloproteinases (MMPs) by
microRNA has emerged as an important factor in human diseases. The aim of this study was …

Spa therapy represents a popular treatment for many rheumatic diseases. The mechanisms
by which immersion in mineral or thermal water or the application of mud alleviates suffering …

An imbalance in gene expressional events skewing chondrocyte anabolic and catabolic
pathways toward the latter causes an aberrant turnover and loss of extracellular matrix …

Osteoarthritis is the most common degenerative musculoskeletal disease. In healthy
cartilage, a low turnover of extracellular matrix molecules occurs. Proper balance of anabolic …