Vaccines comprising innovative adjuvants are rapidly reaching advanced translational
stages, such as the authorized nanotechnology adjuvants in mRNA vaccines against COVID …

The cGAS-STING signaling is an important pathway involved in the regulation of tumor
microenvironment, which affects many cellular functions including immune activation. Its role …

Vaccines are an important tool in the rapidly evolving repertoire of immunotherapies in
oncology. Although cancer vaccines have been investigated for over 30 years, very few …

The cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) signaling
pathway is a key pathway through which the host regulates immune responses by …

Immunotherapy has become a promising research “hotspot” in cancer treatment.“Soldier”
immune cells are not uniform throughout the body; they accumulate mostly in the immune …

Immune checkpoint blockade (ICB) has revolutionized cancer treatment and led to complete
and durable responses, but only for a minority of patients. Resistance to ICB can largely be …

As the first line of host defense against pathogenic infections, innate immunity plays a key
role in antitumor immunotherapy. The cyclic GMP‐AMP synthase (cGAS)‐stimulator of …

Adjuvants are of critical value in vaccine development as they act on enhancing
immunogenicity of antigen and inducing long‐lasting immunity. However, there are only a …

Peptide cancer vaccines have had limited clinical success despite their safety,
characterization and production advantages. We hypothesize that the poor immunogenicity …

Abstract cGAS-STING pathway stands at the forefront of innate immunity and plays a critical
role in regulating adaptive immune responses, making it as a key orchestrator of anti-tumor …