Podocyte-targeted therapies—progress and future directions

K Meliambro, JC He, KN Campbell - Nature Reviews Nephrology, 2024 - nature.com
Podocytes are the key target cells for injury across the spectrum of primary and secondary
proteinuric kidney disorders, which account for up to 90% of cases of kidney failure …

The Pathophysiological Role of Thymosin β4 in the Kidney Glomerulus

WJ Mason, E Vasilopoulou - International Journal of Molecular Sciences, 2023 - mdpi.com
Diseases affecting the glomerulus, the filtration unit of the kidney, are a major cause of
chronic kidney disease. Glomerular disease is characterised by injury of glomerular cells …

[PDF][PDF] Transforming glomerulonephritis care through emerging diagnostics and therapeutics

TA Addissouky, IE El Sayed, MM Ali, MH Alubiady… - J Biomed …, 2024 - probiologists.com
Background Glomerulonephritis refers to inflammation and injury of the glomeruli, the tiny
filtration units within the kidneys. It can arise from various causes like infections …

Cardiotrophin‐1 therapy reduces disease severity in a murine model of glomerular disease

N Perretta‐Tejedor, KL Price, DJ Jafree… - Physiological …, 2024 - Wiley Online Library
Abstract Cardiotrophin‐1 (CT‐1), a member of the interleukin (IL)‐6 cytokine family, has
renoprotective effects in mouse models of acute kidney disease and tubulointerstitial …

Adriamycin-induced nephropathy models: elucidating CKD pathophysiology and advancing therapeutic strategies

M Watanabe, HR Takimoto, N Sasaki - Experimental Animals, 2024 - jstage.jst.go.jp
The Adriamycin-induced nephropathy (AN) model plays a crucial role in advancing our
understanding of and research on chronic kidney disease (CKD). This review outlines …

Vincristine treatment reverses podocyte damage in focal segmental glomerulosclerosis

WJ Mason, JC Chandler, G Pomeranz, KL Price… - bioRxiv, 2024 - biorxiv.org
Introduction: Focal segmental glomerulosclerosis (FSGS) is a significant cause of chronic
kidney disease and triggered by podocyte damage which can result in cytoskeletal …