Evidence from physical sciences in oncology increasingly suggests that the interplay
between the biophysical tumor microenvironment and genetic regulation has significant …

Fibroblasts are typical mesenchymal cells widely distributed throughout the human body
where they (1) synthesise and maintain the extracellular matrix, ensuring the structural role …

Electrically excitable cells such as neurons transmit long-distance calcium or electrical
signals to regulate their physiological functions. While the molecular underpinnings and …

A growing amount of information about the different types, functions, and roles played by
non-coding RNAs (ncRNAs) is becoming available, as more and more research is done …

Increased malignancy and poor treatability associated with solid tumour cancers have
commonly been attributed to mitochondrial calcium (Ca2+) dysregulation. The mitochondrial …

During morphogenesis, epithelial sheets undergo sequential folding to form three-
dimensional organ structures. The resulting folds are often irreversible, ensuring that …

Biomechanical forces are of fundamental importance in biology, diseases, and medicine.
Mechanobiology is an emerging interdisciplinary field that studies how biological …

In this review, we shed light on recent advances regarding the characterization of
biochemical pathways of cellular mechanosensing and mechanotransduction with particular …

Tissue engineers have utilised a variety of three-dimensional (3D) scaffolds for controlling
multicellular dynamics and the resulting tissue microstructures. In particular, cutting-edge …

A fundamental question in mechanobiology is how living cells sense extracellular
mechanical stimuli in the context of cell physiology and pathology. The cellular mechano …