Photochemical approaches to complex chemotypes: applications in natural product synthesis

MD Karkas, JA Porco Jr, CRJ Stephenson - Chemical Reviews, 2016 - ACS Publications
The use of photochemical transformations is a powerful strategy that allows for the formation
of a high degree of molecular complexity from relatively simple building blocks in a single …

Impact of natural compounds on neurodegenerative disorders: from preclinical to pharmacotherapeutics

M Sharifi-Rad, C Lankatillake, DA Dias… - Journal of Clinical …, 2020 - mdpi.com
Among the major neurodegenerative disorders (NDDs), Alzheimer's disease (AD) and
Parkinson's disease (PD), are a huge socioeconomic burden. Over many centuries, people …

Pyridones in drug discovery: Recent advances

Y Zhang, A Pike - Bioorganic & Medicinal Chemistry Letters, 2021 - Elsevier
Pyridones have been utilized as privileged scaffolds in drug discovery. Some of the
important roles where this class of heterocycles have found utility in medicinal chemistry …

Antifungal and antibacterial activities of allicin: A review

A Marchese, R Barbieri, A Sanches-Silva… - Trends in Food Science …, 2016 - Elsevier
Background Up until the early twentieth century infectious diseases were the most common
and serious health problem worldwide, with degenerative disorders only dominating in …

Divergent Total Syntheses of Illicium Sesquiterpenes through Late-Stage Skeletal Reorganization

P Fu, T Liu, Y Shen, X Lei, T Xiao, P Chen… - Journal of the …, 2023 - ACS Publications
We disclose unified, protecting-group-free, bioinspired divergent total syntheses of eight allo-
cedrane and seco-prezizaane Illicium sesquiterpenes and formal syntheses of five …

Discovery of Neuritogenic Securinega Alkaloids from Flueggea suffruticosa by a Building Blocks‐Based Molecular Network Strategy

QF He, ZL Wu, L Li, WY Sun, GY Wang… - Angewandte Chemie …, 2021 - Wiley Online Library
A combined strategy of building blocks recognition and molecular network construction,
termed the building blocks‐based molecular network (BBMN), was first presented to …

One-Carbon Insertion and Polarity Inversion Enabled a Pyrrole Strategy to the Total Syntheses of Pyridine-Containing Lycopodium Alkaloids: Complanadine A and …

D Ma, BS Martin, KS Gallagher, T Saito… - Journal of the American …, 2021 - ACS Publications
Complanadine A and lycodine are representative members of the Lycopodium alkaloids
with a characteristic pyridine-containing tetracyclic skeleton. Complanadine A has …

Applications of Knoevenagel condensation reaction in the total synthesis of natural products

MM Heravi, F Janati, V Zadsirjan - Monatshefte für Chemie-Chemical …, 2020 - Springer
The Knoevenagel condensation reaction is a prominent organic reaction commonly being
utilized in the total synthesis of natural and biologically potent products as a vital and …

Hericioic Acids A–G and Hericiofuranoic Acid; Neurotrophic Agents from Cultures of the European Mushroom Hericium flagellum

WC Sum, SS Ebada, M Kirchenwitz… - Journal of Agricultural …, 2023 - ACS Publications
Neurodegenerative diseases are currently posing huge social, economic, and healthcare
burdens among the aged populations worldwide with few and only palliative treatment …

Development of a Terpene Feedstock-Based Oxidative Synthetic Approach to the Illicium Sesquiterpenes

K Hung, ML Condakes, LFT Novaes… - Journal of the …, 2019 - ACS Publications
The Illicium sesquiterpenes are a family of natural products containing over 100 highly
oxidized and structurally complex members, many of which display interesting biological …