Executive summary Despite substantial progress in reducing the global impact of many non-
communicable diseases, including heart disease and cancer, morbidity and mortality due to …

Chronic airflow limitation is the common denominator of patients with chronic obstructive
pulmonary disease (COPD). However, it is not possible to predict morbidity and mortality of …

Objectives The objective of this article is to describe the unique challenges and present
potential solutions and approaches for economic evaluations of precision medicine (PM) …

Problem definition: Personalized medicine (PM) seeks the best treatment for each patient
among a set of available treatment methods. Because a specific treatment does not work …

Question What is the cost-effectiveness of respiratory physiotherapy interventions for people
with chronic obstructive pulmonary disease? Design Systematic review of full economic …

Background. Evaluation of personalized treatment options requires health economic models
that include multiple patient characteristics. Patient-level discrete-event simulation (DES) …

Objectives Chronic obstructive pulmonary disease (COPD) guidelines advocate treatment
with combinations of long-acting bronchodilators for patients with COPD who have …

Abstract Background and Objectives As regression approaches have been used more
recently to model the effectiveness and health-related quality of life (HRQOL) of novel …

Objectives Developing and validating a discrete event simulation model that is able to model
patients with heart failure managed with usual care or an early warning system (with or …

The number of people affected by chronic obstructive pulmonary disease (COPD) is
increasing and the hospital readmission rate is remarkably high. Therefore, healthcare …