Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels comprise a small
subfamily of proteins within the superfamily of pore-loop cation channels. In mammals, the …

Pacemaking is a basic physiological process, and the cellular mechanisms involved in this
function have always attracted the keen attention of investigators. The “funny”(I f) current …

Highlights•Hyperpolarization-activated cyclic nucleotide-gated (HCN) cation channels are
involved in multiple physiological processes.•HCN channels are excellent targets of various …

Hyperpolarization-activated, cyclic nucleotide–gated (HCN) channels are important
members of the voltage-gated pore loop channels family. They show unique features: they …

Plant Cyclic Nucleotide-Gated Channels: New Insights on Their Functions and Regulation |
Plant Physiology | Oxford Academic Skip to Main Content Advertisement Oxford Academic …

In mammals cardiac rate is determined by the duration of the diastolic depolarization of
sinoatrial node (SAN) cells which is mainly determined by the pacemaker If current. f …

Epilepsy is the third most common brain disorder and affects millions of people. Epilepsy is
characterized by the occurrence of spontaneous seizures, that is, bursts of synchronous …

Hyperpolarization-activated, cyclic nucleotide-sensitive (HCN) channels are key regulators
of subthreshold membrane potentials in excitable cells. The four mammalian HCN channel …

Voltage-gated ion channels are crucial for both neuronal and cardiac excitability. Decades
of research have begun to unravel the intriguing machinery behind voltage sensitivity …

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are key modulators of
neuronal activity by providing the depolarizing cation current I h involved in rhythmogenesis …