The enhancement of wound healing has been a goal of medical practitioners for thousands
of years. The development of chronic, non-healing wounds is a persistent medical problem …

The insulin receptor (IR) gene undergoes differential splicing that generates two IR isoforms,
IR-A and IR-B. The physiological roles of IR isoforms are incompletely understood and …

An increased rate of lipid synthesis in cancerous tissues has long been recognised as an
important aspect of the rewired metabolism of transformed cells. However, the contribution of …

Insulin is a major endocrine hormone also involved in the regulation of energy and lipid
metabolism via the activation of an intracellular signaling cascade involving the insulin …

The healing of diabetic foot ulcers (DFUs) is a major challenge for clinical treatment because
of the hyperglycemic and acidic microenvironment in the wound area. In this study, a self …

Diabetes wounds take longer to heal due to extended inflammation, decreased
angiogenesis, bacterial infection, and oxidative stress. These factors underscore the need …

The number of patients with non-healing wounds is generally increasing globally, placing a
huge social and economic burden on every country. The complexity of the wound-healing …

Overactivation and persistent chronic inflammation are the major pathogenic characteristics
of diabetic‐impaired healing, and diabetic wound healing can be promoted by stimulating …

Pancreatic islet transplantation still represents a promising therapeutic strategy for curative
treatment of type 1 diabetes mellitus. However, a limited number of organ donors and …

Epidemiological studies have related hyperinsulinemia and type 2 diabetes to an increased
breast cancer risk, an aggressive and metastatic phenotype, and a poor prognosis …