As an essential component of the maternal-fetal interface, the placental syncytiotrophoblast
layer contributes to a successful pregnancy by secreting hormones necessary for …

Comprehensively understanding the female reproductive system is crucial for safeguarding
fertility and preventing diseases concerning women's health. With the capacity to simulate …

Pathologies associated with uteroplacental hypoxia, such as preeclampsia are among the
leading causes of maternal and perinatal morbidity in the world. Its fundamental …

Proper placental vascularization is vital for pregnancy outcomes, but assessing it with
animal models and human explants has limitations. We introduce a 3D in vitro model of …

This review considers fully three-dimensional biomaterial environments of varying
complexity as these pertain to research on the placenta. The developments in placental cell …

In order to prevent new pathogen outbreaks and avoid possible new global health threats, it
is important to study the mechanisms of microbial pathogenesis, screen new antiviral agents …

The effects of endocrine-disrupting compounds (EDCs) on the placenta, a critical gestational
organ for xenobiotic protection, are well reported; however, models to determine the role of …

One of the most complex human physiological processes to study is pregnancy. Standard
animal models, as well as two-dimensional models, lack the complexity and biological …

Abstract New Approach Methodologies (NAMs), broadly understood to include in silico, in
chemico, in vitro and ex vivo methods, show great potential in advancing risk assessment …

Preeclampsia (PE) occurs annually in 8% of pregnancies. Patients without risk factors
represent 10% of these. There are currently no first‐trimester biochemical markers that …