Mammalian stress granules and P bodies at a glance

CL Riggs, N Kedersha, P Ivanov… - Journal of cell …, 2020 - journals.biologists.com
Stress granules (SGs) and processing bodies (PBs) are membraneless ribonucleoprotein-
based cellular compartments that assemble in response to stress. SGs and PBs form …

Stress granules and processing bodies in translational control

P Ivanov, N Kedersha… - Cold Spring Harbor …, 2019 - cshperspectives.cshlp.org
Stress granules (SGs) and processing bodies (PBs) are non-membrane-enclosed RNA
granules that dynamically sequester translationally inactive messenger ribonucleoprotein …

The Parkinson's disease protein alpha-synuclein is a modulator of processing bodies and mRNA stability

E Hallacli, C Kayatekin, S Nazeen, XH Wang… - Cell, 2022 - cell.com
Alpha-synuclein (αS) is a conformationally plastic protein that reversibly binds to cellular
membranes. It aggregates and is genetically linked to Parkinson's disease (PD). Here, we …

Conformational dynamics of intrinsically disordered proteins regulate biomolecular condensate chemistry

A Abyzov, M Blackledge, M Zweckstetter - Chemical Reviews, 2022 - ACS Publications
Motions in biomolecules are critical for biochemical reactions. In cells, many biochemical
reactions are executed inside of biomolecular condensates formed by ultradynamic …

N6-methyladenosine modulates messenger RNA translation efficiency

X Wang, BS Zhao, IA Roundtree, Z Lu, D Han, H Ma… - Cell, 2015 - cell.com
Summary N 6-methyladenosine (m 6 A) is the most abundant internal modification in
mammalian mRNA. This modification is reversible and non-stoichiometric and adds another …

Liquid–liquid phase separation and its mechanistic role in pathological protein aggregation

WM Babinchak, WK Surewicz - Journal of molecular biology, 2020 - Elsevier
Liquid–liquid phase separation (LLPS) of proteins underlies the formation of membrane-less
organelles. While it has been recognized for some time that these organelles are of key …

Stress granules, RNA-binding proteins and polyglutamine diseases: too much aggregation?

A Marcelo, R Koppenol, LP de Almeida, CA Matos… - Cell death & …, 2021 - nature.com
Stress granules (SGs) are membraneless cell compartments formed in response to different
stress stimuli, wherein translation factors, mRNAs, RNA-binding proteins (RBPs) and other …

N6-methyladenosine-dependent regulation of messenger RNA stability

X Wang, Z Lu, A Gomez, GC Hon, Y Yue, D Han, Y Fu… - Nature, 2014 - nature.com
Abstract N 6-methyladenosine (m6A) is the most prevalent internal (non-cap) modification
present in the messenger RNA of all higher eukaryotes,. Although essential to cell viability …

Y-box protein 1 is required to sort microRNAs into exosomes in cells and in a cell-free reaction

MJ Shurtleff, MM Temoche-Diaz, KV Karfilis, S Ri… - elife, 2016 - elifesciences.org
Exosomes are small vesicles that are secreted from metazoan cells and may convey
selected membrane proteins and small RNAs to target cells for the control of cell migration …

m6A-binding YTHDF proteins promote stress granule formation

Y Fu, X Zhuang - Nature chemical biology, 2020 - nature.com
Diverse RNAs and RNA-binding proteins form phase-separated, membraneless granules in
cells under stress conditions. However, the role of the prevalent mRNA methylation, m6A …