Bioavailability enhancement techniques for poorly aqueous soluble drugs and therapeutics

DV Bhalani, B Nutan, A Kumar, AK Singh Chandel - Biomedicines, 2022 - mdpi.com
The low water solubility of pharmacoactive molecules limits their pharmacological potential,
but the solubility parameter cannot compromise, and so different approaches are employed …

Intraperitoneal route of drug administration: should it be used in experimental animal studies?

A Al Shoyaib, SR Archie, VT Karamyan - Pharmaceutical research, 2020 - Springer
Intraperitoneal (IP) route of drug administration in laboratory animals is a common practice
in many in vivo studies of disease models. While this route is an easy to master, quick …

Senolytics reduce coronavirus-related mortality in old mice

CD Camell, MJ Yousefzadeh, Y Zhu, LGPL Prata… - Science, 2021 - science.org
INTRODUCTION The COVID-19 pandemic revealed enhanced vulnerability of the elderly
and chronically ill to adverse outcomes upon severe acute respiratory syndrome coronavirus …

Role of the encapsulation in bioavailability of phenolic compounds

J Grgić, G Šelo, M Planinić, M Tišma, A Bucić-Kojić - Antioxidants, 2020 - mdpi.com
Plant-derived phenolic compounds have multiple positive health effects for humans
attributed to their antioxidative, anti-inflammatory, and antitumor properties, etc. These …

Nanoemulsion: Concepts, development and applications in drug delivery

Y Singh, JG Meher, K Raval, FA Khan… - Journal of controlled …, 2017 - Elsevier
Nanoemulsions are biphasic dispersion of two immiscible liquids: either water in oil (W/O) or
oil in water (O/W) droplets stabilized by an amphiphilic surfactant. These come across as …

Opportunities and challenges in enhancing the bioavailability and bioactivity of dietary flavonoids: A novel delivery system perspective

D Yuan, Y Guo, F Pu, C Yang, X Xiao, H Du, J He, S Lu - Food Chemistry, 2024 - Elsevier
Flavonoids have multiple favorable bioactivities including antioxidant, anti-inflammatory, and
antitumor. Currently, flavonoid-containing dietary supplements are widely tested in clinical …

[HTML][HTML] Techniques for formulation of nanoemulsion drug delivery system: a review

M Kumar, RS Bishnoi, AK Shukla… - Preventive nutrition and …, 2019 - ncbi.nlm.nih.gov
Nanoemulsion drug delivery systems are advanced modes for delivering and improving the
bioavailability of hydrophobic drugs and the drug which have high first pass metabolism …

Fisetin: a dietary antioxidant for health promotion

N Khan, DN Syed, N Ahmad… - Antioxidants & redox …, 2013 - liebertpub.com
Significance: Diet-derived antioxidants are now being increasingly investigated for their
health-promoting effects, including their role in the chemoprevention of cancer. In general …

Pharmaceutical dispersion techniques for dissolution and bioavailability enhancement of poorly water-soluble drugs

X Zhang, H Xing, Y Zhao, Z Ma - Pharmaceutics, 2018 - mdpi.com
Over the past decades, a large number of drugs as well as drug candidates with poor
dissolution characteristics have been witnessed, which invokes great interest in enabling …

Nanoemulsions in drug delivery: formulation to medical application

HH Tayeb, F Sainsbury - Nanomedicine, 2018 - Taylor & Francis
Nanoscale oil-in-water emulsions (NEs), heterogeneous systems of two immiscible liquids
stabilized by emulsifiers or surfactants, show great potential in medical applications because …