Innovations and advances in modelling and measuring pain in animals
Best practices in preclinical algesiometry (pain behaviour testing) have shifted over the past
decade as a result of technological advancements, the continued dearth of translational …
decade as a result of technological advancements, the continued dearth of translational …
The role of calcitonin gene–related peptide in peripheral and central pain mechanisms including migraine
S Iyengar, MH Ossipov, KW Johnson - Pain, 2017 - journals.lww.com
Calcitonin gene–related peptide (CGRP) is a 37-amino acid peptide found primarily in the C
and Aδ sensory fibers arising from the dorsal root and trigeminal ganglia, as well as the …
and Aδ sensory fibers arising from the dorsal root and trigeminal ganglia, as well as the …
Spatial transcriptomics of dorsal root ganglia identifies molecular signatures of human nociceptors
Nociceptors are specialized sensory neurons that detect damaging or potentially damaging
stimuli and are found in the dorsal root ganglia (DRG) and trigeminal ganglia. These …
stimuli and are found in the dorsal root ganglia (DRG) and trigeminal ganglia. These …
Studying human nociceptors: from fundamentals to clinic
Chronic pain affects one in five of the general population and is the third most important
cause of disability-adjusted life-years globally. Unfortunately, treatment remains inadequate …
cause of disability-adjusted life-years globally. Unfortunately, treatment remains inadequate …
Nociceptors: the sensors of the pain pathway
AE Dubin, A Patapoutian - The Journal of clinical …, 2010 - Am Soc Clin Investig
Specialized peripheral sensory neurons known as nociceptors alert us to potentially
damaging stimuli at the skin by detecting extremes in temperature and pressure and injury …
damaging stimuli at the skin by detecting extremes in temperature and pressure and injury …
Quantitative differences in neuronal subpopulations between mouse and human dorsal root ganglia demonstrated with RNAscope in situ hybridization
Next-generation transcriptomics in combination with imaging-based approaches have
emerged as powerful tools for the characterization of dorsal root ganglion (DRG) neuronal …
emerged as powerful tools for the characterization of dorsal root ganglion (DRG) neuronal …
Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli
DJ Cavanaugh, H Lee, L Lo… - Proceedings of the …, 2009 - National Acad Sciences
Behavioral responses to painful stimuli require peripheral sensory neurons called
nociceptors. Electrophysiological studies show that most C-fiber nociceptors are polymodal …
nociceptors. Electrophysiological studies show that most C-fiber nociceptors are polymodal …
Fremanezumab—a humanized monoclonal anti-CGRP antibody—inhibits thinly myelinated (Aδ) but not unmyelinated (C) meningeal nociceptors
Calcitonin gene-related peptide (CGRP), the most abundant neuropeptide in primary
afferent sensory neurons, is strongly implicated in the pathophysiology of migraine …
afferent sensory neurons, is strongly implicated in the pathophysiology of migraine …
The CysLT2R receptor mediates leukotriene C4-driven acute and chronic itch
Acute and chronic itch are burdensome manifestations of skin pathologies including allergic
skin diseases and atopic dermatitis, but the underlying molecular mechanisms are not well …
skin diseases and atopic dermatitis, but the underlying molecular mechanisms are not well …
Current understanding of trigeminal ganglion structure and function in headache
K Messlinger, AF Russo - Cephalalgia, 2019 - journals.sagepub.com
Introduction The trigeminal ganglion is unique among the somatosensory ganglia regarding
its topography, structure, composition and possibly some functional properties of its cellular …
its topography, structure, composition and possibly some functional properties of its cellular …