Human kidney organoids: progress and remaining challenges
R Nishinakamura - Nature Reviews Nephrology, 2019 - nature.com
Kidney organoids are regarded as important tools with which to study the development of
the normal and diseased human kidney. Since the first reports of human pluripotent stem …
the normal and diseased human kidney. Since the first reports of human pluripotent stem …
Emerging roles of Wnt ligands in human colorectal cancer
X Nie, H Liu, L Liu, YD Wang, WD Chen - Frontiers in oncology, 2020 - frontiersin.org
Colorectal cancer (CRC) is the fourth leading cause of cancer death worldwide, and
constitutive activation of the Wnt signaling pathway is universal in most CRC cases. Wnt …
constitutive activation of the Wnt signaling pathway is universal in most CRC cases. Wnt …
Cell transcriptomic atlas of the non-human primate Macaca fascicularis
Studying tissue composition and function in non-human primates (NHPs) is crucial to
understand the nature of our own species. Here we present a large-scale cell transcriptomic …
understand the nature of our own species. Here we present a large-scale cell transcriptomic …
Development of the mammalian kidney
AP McMahon - Current topics in developmental biology, 2016 - Elsevier
The basic unit of kidney function is the nephron. In the mouse, around 14,000 nephrons form
in a 10-day period extending into early neonatal life, while the human fetus forms the adult …
in a 10-day period extending into early neonatal life, while the human fetus forms the adult …
Mammalian kidney development: principles, progress, and projections
MH Little, AP McMahon - Cold Spring Harbor …, 2012 - cshperspectives.cshlp.org
The mammalian kidney is a vital organ with considerable cellular complexity and functional
diversity. Kidney development is notable for requiring distinct but coincident tubulogenic …
diversity. Kidney development is notable for requiring distinct but coincident tubulogenic …
Conserved and divergent features of mesenchymal progenitor cell types within the cortical nephrogenic niche of the human and mouse kidney
Cellular interactions among nephron, interstitial, and collecting duct progenitors drive
mammalian kidney development. In mice, Six2+ nephron progenitor cells (NPCs) and …
mammalian kidney development. In mice, Six2+ nephron progenitor cells (NPCs) and …
Identification of a multipotent self-renewing stromal progenitor population during mammalian kidney organogenesis
A Kobayashi, JW Mugford, AM Krautzberger, N Naiman… - Stem cell reports, 2014 - cell.com
The mammalian kidney is a complex organ consisting of multiple cell types. We previously
showed that the Six2-expressing cap mesenchyme is a multipotent self-renewing progenitor …
showed that the Six2-expressing cap mesenchyme is a multipotent self-renewing progenitor …
FGF9 and FGF20 maintain the stemness of nephron progenitors in mice and man
The identity of niche signals necessary to maintain embryonic nephron progenitors is
unclear. Here we provide evidence that Fgf20 and Fgf9, expressed in the niche, and Fgf9 …
unclear. Here we provide evidence that Fgf20 and Fgf9, expressed in the niche, and Fgf9 …
Kidney organoids: accurate models or fortunate accidents
MH Little, AN Combes - Genes & Development, 2019 - genesdev.cshlp.org
There are now many reports of human kidney organoids generated via the directed
differentiation of human pluripotent stem cells (PSCs) based on an existing understanding of …
differentiation of human pluripotent stem cells (PSCs) based on an existing understanding of …
Single cell analysis of the developing mouse kidney provides deeper insight into marker gene expression and ligand-receptor crosstalk
Recent advances in the generation of kidney organoids and the culture of primary nephron
progenitors from mouse and human have been based on knowledge of the molecular basis …
progenitors from mouse and human have been based on knowledge of the molecular basis …