▪ Abstract In vitro selection allows rare functional RNA or DNA molecules to be isolated from
pools of over 1015 different sequences. This approach has been used to identify RNA and …

▪ Abstract The past few years have seen exciting advances in understanding the structure
and function of catalytic RNA. Crystal structures of several ribozymes have provided detailed …

Ribonuclease P (RNase P) is the endoribonuclease that generates the mature 5′-ends of
tRNA by removal of the 5′-leader elements of precursor-tRNAs. This enzyme has been …

▪ Abstract Since the discovery of enzymes as biological catalysts, study of their enormous
catalytic power and exquisite specificity has been central to biochemistry. Nevertheless …

Abstract Ribonuclease P (RNase P) is a ubiquitous endonuclease that catalyses the
maturation of the 5′ end of transfer RNA (tRNA). Although it carries out a biochemically …

Transfer RNA is an essential adapter molecule that is found across all three domains of life.
The primary role of transfer RNA resides in its critical involvement in the accurate translation …

A classic approach in biology, both organismal and cellular, is to compare morphologies in
order to glean structural and functional commonalities. The comparative approach has also …

The universally conserved ribonucleoprotein RNase P is involved in the processing of tRNA
precursor transcripts. RNase P consists of one RNA and, depending on its origin, a variable …

The x-ray crystal structure of a 417-nt ribonuclease P RNA from Bacillus stearothermophilus
was solved to 3.3-Å resolution. This RNA enzyme is constructed from a number of coaxially …

The hammerhead ribozyme is a small RNA motif that self cleaves at a specific
phosphodiester bond to produce 2′, 3′ cyclic phosphate and 5′ hydroxyl termini …