Versatile types of inorganic/organic NIR-IIa/IIb fluorophores: from strategic design toward molecular imaging and theranostics

Y Liu, Y Li, S Koo, Y Sun, Y Liu, X Liu, Y Pan… - Chemical …, 2021 - ACS Publications
In vivo imaging in the second near-infrared window (NIR-II, 1000–1700 nm), which enables
us to look deeply into living subjects, is producing marvelous opportunities for biomedical …

Visible-to-NIR-light activated release: from small molecules to nanomaterials

R Weinstain, T Slanina, D Kand, P Klan - Chemical reviews, 2020 - ACS Publications
Photoactivatable (alternatively, photoremovable, photoreleasable, or photocleavable)
protecting groups (PPGs), also known as caged or photocaged compounds, are used to …

Taking phototherapeutics from concept to clinical launch

BM Vickerman, EM Zywot, TK Tarrant… - Nature Reviews …, 2021 - nature.com
More than four decades have passed since the first example of a light-activated (caged)
compound was described. In the intervening years, a large number of light-responsive …

Light: a magical tool for controlled drug delivery

Y Tao, HF Chan, B Shi, M Li… - Advanced Functional …, 2020 - Wiley Online Library
Light is a particularly appealing tool for on‐demand drug delivery due to its noninvasive
nature, ease of application, and exquisite temporal and spatial control. Great progress is …

Light-induced control of protein destruction by opto-PROTAC

J Liu, H Chen, L Ma, Z He, D Wang, Y Liu, Q Lin… - Science …, 2020 - science.org
By hijacking endogenous E3 ligase to degrade protein targets via the ubiquitin-proteasome
system, PROTACs (PRoteolysis TArgeting Chimeras) provide a new strategy to inhibit …

A Near‐Infrared Light‐Activated Photocage Based on a Ruthenium Complex for Cancer Phototherapy

G He, M He, R Wang, X Li, H Hu… - Angewandte Chemie …, 2023 - Wiley Online Library
Conventional photocages only respond to short wavelength light, which is a significant
obstacle to developing efficient phototherapy in vivo. The development of photocages …

Optochemical control of biological processes in cells and animals

N Ankenbruck, T Courtney, Y Naro… - Angewandte Chemie …, 2018 - Wiley Online Library
Biological processes are naturally regulated with high spatial and temporal control, as is
perhaps most evident in metazoan embryogenesis. Chemical tools have been extensively …

Stimulus-cleavable chemistry in the field of controlled drug delivery

Y Xue, H Bai, B Peng, B Fang, J Baell, L Li… - Chemical Society …, 2021 - pubs.rsc.org
Stimulus-cleavable nanoscale drug delivery systems are receiving significant attention
owing to their capability of achieving exquisite control over drug release via the exposure to …

Mechanisms of drug release in nanotherapeutic delivery systems

PT Wong, SK Choi - Chemical reviews, 2015 - ACS Publications
Targeted drug delivery refers to an established therapeutic strategy that develops platforms
and nanoscale devices for selective delivery of small drug molecules and therapeutic genes …

Light‐triggered transformable ferrous ion delivery system for photothermal primed chemodynamic therapy

T He, Y Yuan, C Jiang, NT Blum, J He… - Angewandte …, 2021 - Wiley Online Library
Chemodynamic therapy (CDT) involves the catalytic generation of highly toxic hydroxyl
radicals (. OH) from hydrogen peroxide (H2O2) through metal‐ion‐mediated Fenton or …