Tailoring porous silicon for biomedical applications: from drug delivery to cancer immunotherapy

W Li, Z Liu, F Fontana, Y Ding, D Liu… - Advanced …, 2018 - Wiley Online Library
In the past two decades, porous silicon (PSi) has attracted increasing attention for its
potential biomedical applications. With its controllable geometry, tunable nanoporous …

The potential of protein–nanomaterial interaction for advanced drug delivery

Q Peng, H Mu - Journal of Controlled Release, 2016 - Elsevier
Nanomaterials, like nanoparticles, micelles, nano-sheets, nanotubes and quantum dots,
have great potentials in biomedical fields. However, their delivery is highly limited by the …

Immunogene therapy with fusogenic nanoparticles modulates macrophage response to Staphylococcus aureus

B Kim, HB Pang, J Kang, JH Park, E Ruoslahti… - Nature …, 2018 - nature.com
The incidence of adverse effects and pathogen resistance encountered with small molecule
antibiotics is increasing. As such, there is mounting focus on immunogene therapy to …

Inorganic porous nanoparticles for drug delivery in antitumoral therapy

J Parra‐Nieto, MAG Del Cid, IA de Cárcer… - Biotechnology …, 2021 - Wiley Online Library
The use of nanoparticles in oncology to deliver chemotherapeutic agents has received
considerable attention in the last decades due to their tendency to be passively accumulated …

Tumor-targeting, microRNA-silencing porous silicon nanoparticles for ovarian cancer therapy

A Bertucci, KH Kim, J Kang, JM Zuidema… - … applied materials & …, 2019 - ACS Publications
Silencing of aberrantly expressed microRNAs (miRNAs or miRs) has emerged as one of the
strategies for molecular targeted cancer therapeutics. In particular, miR-21 is an oncogenic …

Polymeric mesoporous silica nanoparticles for enhanced delivery of 5-fluorouracil in vitro

T Moodley, M Singh - Pharmaceutics, 2019 - mdpi.com
There is a need for the improvement of conventional cancer treatment strategies by
incorporation of targeted and non-invasive procedures aimed to reduce side-effects, drug …

[HTML][HTML] Black porous silicon as a photothermal agent and immunoadjuvant for efficient antitumor immunotherapy

W Xu, C Pang, C Song, J Qian, S Feola, V Cerullo… - Acta Biomaterialia, 2022 - Elsevier
Photothermal therapy (PTT) in combination with other treatment modalities has shown great
potential to activate immunotherapy against tumor metastasis. However, the nanoparticles …

Temperature-responsive polymeric nanospheres containing methotrexate and gold nanoparticles: A multi-drug system for theranostic in rheumatoid arthritis

SAC Lima, S Reis - Colloids and Surfaces B: Biointerfaces, 2015 - Elsevier
Inflammation plays a crucial role in rheumatoid arthritis progress. In the present work, a
novel stealth polymeric nanospheres platform able to carry anti-inflammatory drugs and an …

Temperature responsive porous silicon nanoparticles for cancer therapy–spatiotemporal triggering through infrared and radiofrequency electromagnetic heating

K Tamarov, W Xu, L Osminkina, S Zinovyev… - Journal of Controlled …, 2016 - Elsevier
One critical functionality of the carrier system utilized in targeted drug delivery is its ability to
trigger the release of the therapeutic cargo once the carrier has reached its target. External …

Gold Nanorods, DNA Origami, and Porous Silicon Nanoparticle-functionalized Biocompatible Double Emulsion for Versatile Targeted Therapeutics and Antibody …

F Kong, H Zhang, X Qu, X Zhang, D Chen… - … (Deerfield Beach, Fla …, 2016 - europepmc.org
Gold nanorods, DNA origami, and porous silicon nanoparticle-functionalized biocompatible
double emulsion are developed for versatile molecular targeted therapeutics and antibody …