Interferon family cytokines in obesity and insulin sensitivity

LY Huang, CJ Chiu, CH Hsing, YH Hsu - Cells, 2022 - mdpi.com
Obesity and its associated complications are global public health concerns. Metabolic
disturbances and immune dysregulation cause adipose tissue stress and dysfunction in …

Obesity dysregulates the pulmonary antiviral immune response

M Almond, HA Farne, MM Jackson, A Jha… - Nature …, 2023 - nature.com
Obesity is a well-recognized risk factor for severe influenza infections but the mechanisms
underlying susceptibility are poorly understood. Here, we identify that obese individuals …

Metabolic syndrome and aberrant immune responses to viral infection and vaccination: Insights from small animal models

E Geerling, M Hameed, J Weger-Lucarelli… - Frontiers in …, 2022 - frontiersin.org
This review outlines the propensity for metabolic syndrome (MetS) to induce elevated
disease severity, higher mortality rates post-infection, and poor vaccination outcomes for …

Metabolic syndrome enhances SARS-CoV-2 disease severity and reduces mRNA vaccine efficacy in a mouse model

E Geeling, ET Stone, D Carpenter, A Dickson, J Brien… - bioRxiv, 2025 - biorxiv.org
Metabolic syndrome (MetS) is a cluster of pathophysiological conditions linked to the
disruption of metabolic processes associated with energy storage and consumption …

Obesity and Respiratory Infections Including COVID-19

P Mancuso - Obesity and Lung Disease: A Guide to …, 2024 - Springer
Obesity is a well-known risk factor for cardiometabolic disease and is now recognized as an
underlying condition linked to immune dysfunction. During the recent COVID-19 and 2009 …

Intestinal epigenomic alterations are associated with a dysregulated nutrient absorption phenotype in obesity

DS Badurdeen, Z Li, JH Lee, T Ma, AV Bhagwate… - bioRxiv, 2024 - biorxiv.org
Obesity is an epidemic with myriad health effects, but little is understood regarding individual
obese phenotypes and how they may respond to therapy. Epigenetic changes associated …

Why obese people are more susceptible to viral infections

O Katsoulis - communities.springernature.com
Obesity is a known risk factor for severe influenza infections but the mechanisms underlying
susceptibility are poorly understood. Here, we identify that the obesity-related hormone …