Abstract Overactive phosphoinositide 3-kinase (PI3K) in cancer and immune dysregulation
has spurred extensive efforts to develop therapeutic PI3K inhibitors. Although progress has …

Over the past two decades, new insights have positioned phosphoinositide 3-kinase-γ
(PI3Kγ) as a context-dependent modulator of immunity and inflammation. Recent advances …

Infection of T cells by Epstein-Barr virus (EBV) causes chronic active EBV infection (CAEBV)
characterized by T cell lymphoproliferative disorders (T-LPD) of unclear etiology. Here, we …

Autosomal dominant gain-of-function mutations in the PIK3CD gene encoding the catalytic
subunit p110δ of phosphoinositide 3-kinase-δ (PI3K-δ) or autosomal dominant loss-of …

Abstract Activated phosphatidylinositol 3-kinase-δ (PI3K-δ) syndrome (APDS) is a rare
primary combined immunodeficiency caused by either dominant gain-of-function mutations …

Abstract Activated phosphoinositide-3-kinase (PI3K) δ syndrome (APDS) is an inborn error
of immunity characterised by immune dysregulation. Since the discovery of genetic …

PI3K signalling is required for activation, differentiation, and trafficking of T cells. PI3Kδ, the
dominant PI3K isoform in T cells, has been extensively characterised using PI3Kδ mutant …

Gain-of-function mutations in the PIK3CD gene result in activated phosphoinositide 3-kinase
δ syndrome type 1 (APDS1). This syndrome is a life-threatening combined …

Phosphoinositide 3-kinase p110 delta (PI3K p110δ) is pivotal for CD8+ T cell immune
responses. The current study explores PI3K p110δ induction and repression of antigen …

Methods A systematic review was performed according to the Preferred Reporting Items for
Systematic Reviews and Meta-Analyses approach, including all articles published in English …