Drugs are usually biotransformed into new chemical species that may have either toxic or
therapeutic effects. Drug metabolism studies are routinely performed in laboratory animals …

ABCC2/Abcc2 (MRP2/Mrp2) is expressed at major physiological barriers, such as the
canalicular membrane of liver cells, kidney proximal tubule epithelial cells, enterocytes of …

Liver regeneration is a well-orchestrated process that is typically studied in animal models.
Although previous animal studies have offered many insights into liver regeneration, human …

Lack of a small animal model of the human hepatitis C virus (HCV) has impeded
development of antiviral therapies against this epidemic infection. By transplanting normal …

Methyl jasmonate (MeJa) is a well-known plant stress hormone. Upon exposure to stress,
MeJa is produced and causes activation of programmed cell death (PCD) and defense …

Drug metabolism studies and liver tissue engineering necessitate stable hepatocyte cultures
that express liver functions for a minimum of 4 days to 3 weeks. Current techniques, using …

Importance of the field: Hepatotoxicity is the most frequent reason for the withdrawal of an
approved drug from the market. Monolayer culture of hepatocyte in two-dimension, which is …

Background/Aims: Bio-artificial liver support systems for treatment of hepatic failure require
maintained expression of hepatocyte function in vitro. We studied cultures of human …

Heat shock transcription factor A2 (HsfA2) participates in multiple stress responses. To
provide new insights into the role of HsfA2 in the heat stress (HS) response, in vivo …

S‐adenosylmethionine synthetase (SAMS) catalyzes the formation of S‐
adenosylmethionine (SAM) and is essential to normal cell function. There are two forms of …