Chiral spirooxindoles are privileged heterocyclic motifs, which are widely found in natural
alkaloids and pharmaceuticals. Moreover, the construction of chiral spiro-cyclic frameworks …

Recent developments in catalytic asymmetric aldol reactions have been summarized.
Enantioselective aldol reactions are important methods to synthesize β-hydroxy carbonyl …

1. INTRODUCTION Indoline-2, 3-dione or indole-1H-2, 3-dione (Figure 1), commonly known
as isatin, is a well-known natural product found in plants of genus Isatis and in Couropita …

Spirooxindoles have become a privileged skeleton given their broad and promising
activities in various therapeutic areas. The strategies and catalyst systems described here …

The asymmetric organocatalysis is definitely one of the most powerful and versatile tools for
the rapid construction of various spirocyclic oxindoles. In the past few years, a number of …

Spirooxindoles are important synthetic targets possessing extended biological activity and
drug discovery applications. This review focuses on the various strategies for the …

The enantioselective synthesis of spirocycles has been a long time pursued dream for
organic chemists. Since the first pioneering efforts of Tamao and coworkers in the …

In recent years, organocatalysis has enhanced its importance as a tool for the synthesis of
enantiomerically enriched compounds. Among the candidates for organocatalysis, the …

Oxindoles and spirooxindoles are important synthetic targets that are often considered to be
prevalidated with respect to their biological activity and applications for pharmaceutical lead …

The spirooxindole system is the core structure of a variety of medicinal agents and natural
products. 1, 2 In fact, spirooxindole derivatives have been described with different biological …