Treatment advances in sepsis and septic shock: modulating pro-and anti-inflammatory mechanisms

A Marques, C Torre, R Pinto, B Sepodes… - Journal of Clinical …, 2023 - mdpi.com
Sepsis is currently defined as a life-threatening organ dysfunction caused by a dysregulated
host response to infection, and it affects over 25 million people every year. Even more …

[HTML][HTML] Thymosin alpha 1: a comprehensive review of the literature

A Dominari, D Hathaway III, K Pandav… - World journal of …, 2020 - ncbi.nlm.nih.gov
Thymosin alpha 1 is a peptide naturally occurring in the thymus that has long been
recognized for modifying, enhancing, and restoring immune function. Thymosin alpha 1 has …

Expert consensus on the monitoring and treatment of sepsis-induced immunosuppression

F Pei, RQ Yao, C Ren, S Bahrami, TR Billiar… - Military Medical …, 2022 - Springer
Emerged evidence has indicated that immunosuppression is involved in the occurrence and
development of sepsis. To provide clinical practice recommendations on the immune …

Thymosin α1 and its role in viral infectious diseases: the mechanism and clinical application

N Tao, X Xu, Y Ying, S Hu, Q Sun, G Lv, J Gao - Molecules, 2023 - mdpi.com
Thymosin α1 (Tα1) is an immunostimulatory peptide that is commonly used as an immune
enhancer in viral infectious diseases such as hepatitis B, hepatitis C, and acquired immune …

The efficacy of thymosin alpha 1 for severe sepsis (ETASS): a multicenter, single-blind, randomized and controlled trial

J Wu, L Zhou, J Liu, G Ma, Q Kou, Z He, J Chen… - Critical care, 2013 - Springer
Introduction Severe sepsis is associated with a high mortality rate despite implementation of
guideline recommendations. Adjunctive treatment may be efficient and require further …

The severe COVID-19: A sepsis induced by viral infection? And its immunomodulatory therapy

HY Lin - Chinese Journal of Traumatology, 2020 - mednexus.org
COVID-19 is known for its magical infectivity, fast transmission and high death toll based on
the large number of infected people. From the perspective of the clinical manifestation …

Thymosin α1 therapy in critically ill patients with COVID-19: A multicenter retrospective cohort study

M Wu, J Ji, L Zhong, Z Shao, Q Xie, Z Liu… - International …, 2020 - Elsevier
Background COVID-19 characterized by refractory hypoxemia increases patient mortality
because of immunosuppression effects. This study aimed to evaluate the efficacy of …

Immune modulation with thymosin alpha 1 treatment

R King, C Tuthill - Vitamins and hormones, 2016 - Elsevier
Abstract Thymosin alpha 1 (Ta1) is a peptide originally isolated from thymic tissue as the
compound responsible for restoring immune function to thymectomized mice. Ta1 has a …

Novel evidence of Thymosin α1 immunomodulatory properties in SARS-CoV-2 infection: effect on innate inflammatory response in a peripheral blood mononuclear …

D Ricci, MP Etna, M Severa, S Fiore, F Rizzo… - International …, 2023 - Elsevier
The peculiar property of Thymosin alpha 1 (Tα1) to act as master regulator of immune
homeostasis has been successfully defined in different physiological and pathological …

Design and development of a novel peptide for treating intestinal inflammation

L Zhang, X Wei, R Zhang, JN Petitte, D Si, Z Li… - Frontiers in …, 2019 - frontiersin.org
Intestinal inflammatory disorders, such as inflammatory bowel disease (IBD), are associated
with increased pro-inflammatory cytokine secretion in the intestines. Furthermore, intestinal …