Mechanisms underlying overactive bladder and interstitial cystitis/painful bladder syndrome

L Grundy, A Caldwell, SM Brierley - Frontiers in neuroscience, 2018 - frontiersin.org
The bladder is innervated by extrinsic afferents that project into the dorsal horn of the spinal
cord, providing sensory input to the micturition centers within the central nervous system …

Psychology of chronic pelvic pain: prevalence, neurobiological vulnerabilities, and treatment

SR Till, S As-Sanie, A Schrepf - Clinical obstetrics and …, 2019 - journals.lww.com
Patients with pelvic pain suffer from psychological conditions at a disproportionately high
rate compared with their peers. We review environmental, genetic, inflammatory, and …

Effectiveness of acceptance and commitment therapy in central pain sensitization syndromes: a systematic review

CM Galvez-Sánchez, CI Montoro… - Journal of clinical …, 2021 - mdpi.com
Objectives: Acceptance and commitment therapy (ACT) is considered by the American
Psychological Association as an evidence-based treatment for a variety of disorders …

Normalization of magnesium deficiency attenuated mechanical allodynia, depressive-like behaviors, and memory deficits associated with cyclophosphamide-induced …

JL Chen, X Zhou, BL Liu, XH Wei, HL Ding… - Journal of …, 2020 - Springer
Background Bladder-related pain symptoms in patients with bladder pain
syndrome/interstitial cystitis (BPS/IC) are often accompanied by depression and memory …

Variations in bladder pain syndrome/interstitial cystitis (IC) definitions, pathogenesis, diagnostics and treatment: a systematic review and evaluation of national and …

J Pape, G Falconi, TR De Mattos Lourenco… - International …, 2019 - Springer
Introduction and hypothesis Interstitial cystitis (IC) and bladder pain syndrome (BPS) are
challenging and encompassing hypersensitivity disorders of the lower urinary tract. A variety …

Current updates relating to treatment for interstitial cystitis/bladder pain syndrome: systematic review and network meta-analysis

JJ Park, KT Kim, EJ Lee, J Chun, S Lee, SR Shim… - BMC urology, 2024 - Springer
Background Despite the publication of several meta-analyses regarding the efficacy of
certain therapies in helping individuals with interstitial cystitis (IC)/bladder pain syndrome …

The association between exposure to domestic abuse in women and the development of syndromes indicating central nervous system sensitization: a retrospective …

JS Chandan, D Keerthy, KM Gokhale… - … Journal of Pain, 2021 - Wiley Online Library
Background Domestic abuse is a global public health issue. The association between the
development of central sensitivity syndromes (CSS) and previous exposure to domestic …

Cyclophosphamide-induced cystitis results in NLRP3-mediated inflammation in the hippocampus and symptoms of depression in rats

NA Hirshman, FM Hughes Jr, H Jin… - American Journal …, 2020 - journals.physiology.org
Recent breakthroughs demonstrate that peripheral diseases can trigger inflammation in the
brain, causing psychosocial maladies, including depression. While few direct studies have …

Posttraumatic stress disorder in interstitial cystitis/bladder pain syndrome: Relationship to patient phenotype and clinical practice implications

LC McKernan, BN Johnson… - Neurourology and …, 2019 - Wiley Online Library
Purpose The relationship between exposure to abuse and interstitial cystitis/bladder pain
syndrome (IC/BPS) is well‐documented. However, studies have yet to examine …

Exploring the links among borderline personality disorder symptoms, trauma, and pain in patients with chronic pain disorders

BN Johnson, MA Lumley, JS Cheavens… - Journal of …, 2020 - Elsevier
Objective Chronic pain and borderline personality disorder (BPD) are commonly comorbid
and jointly associated with increased symptoms of both disorders and clinical and functional …