Transcriptional activation throughout the eukaryotic lineage has been tightly linked with
disruption of nucleosome organization at promoters, enhancers, silencers, insulators and …

Chromatin immunoprecipitation experiments followed by sequencing (ChIP–seq) detect
protein–DNA binding events and chemical modifications of histone proteins. Challenges in …

Eukaryotic genomes contain a variety of structured patterns: repetitive elements, binding
sites of DNA and RNA associated proteins, splice sites, and so on. Often, these structured …

Translating data to knowledge and actionable insights is the Holy Grail for many scientific
fields, including biology. The unprecedented massive and heterogeneous data have created …

Genome-wide profiling of open chromatin regions using DNase I and high-throughput
sequencing (DNase-seq) is an increasingly popular approach for finding and studying …

ChIP-Seq (chromatin immunoprecipitation sequencing) has provided the advantage for
finding motifs as ChIP-Seq experiments narrow down the motif finding to binding site …

An increasing number of anticancer therapeutic agents target specific mutant proteins that
are expressed by many different tumor types. Recent evidence suggests that the selection of …

Chromatin immunoprecipitation coupled with next-generation sequencing (ChIP-seq) is a
powerful technology to identify the genome-wide locations of transcription factors and other …

Transcription factors (TFs) are regulatory proteins which bind to a specific DNA region
known as the transcription factor binding regions (TFBRs) to regulate the rate of transcription …

Nowadays, chromatin immunoprecipitation followed by next-generation sequencing, often
referred to as ChIP-Seq, has become an industry standard to study a landscape of DNA …