The aryl hydrocarbon receptor (AHR) is a nuclear receptor that modulates the response to
environmental stimuli. It was recognized historically for its role in toxicology but, in recent …

The aryl hydrocarbon receptor (AhR) has long been implicated in the induction of a battery
of genes involved in the metabolism of xenobiotics and endogenous compounds. AhR is a …

Conventional therapies for cancer treatment have posed many challenges, including toxicity,
multidrug resistance and economic expenses. In contrast, complementary alternative …

Irisin is a hormone-like molecule mainly released by skeletal muscles in response to
exercise. Irisin induces browning of the white adipose tissue and has been shown to …

Simple Summary Cancer is driven by the excessive activity of growth-promoting genes and
deficient activity of the genes that restrain cell growth. Genes that suppress cell growth …

Cruciferous vegetables and oilseeds are rich in glucosinolates that can transform into
isothiocyanates upon enzymic hydrolysis during post-harvest handling, food preparation …

Macrophages are versatile phagocytic cells in immune system with immunoregulatory
functions. However, the removal of apoptotic cells by macrophages is disturbed in systemic …

Abstract Indole-3-carbinol (I3C) is a plant-derived phytochemical produced when raw
cruciferous vegetables are chopped, and their plant cells are damaged. I3C is an orally …

Strategies for treating myocardial ischemia in the clinic usually include re-canalization of the
coronary arteries to restore blood supply to the myocardium. However, myocardial …

Abstract Aryl Hydrocarbon Receptor (AhR) constitutes a major network hub of genomic and
non-genomic signaling pathways, connecting host's immune cells to environmental factors. It …