Sepsis and septic shock are among the leading causes of death in intensive care units
worldwide. Numerous studies on their pathophysiology have revealed an imbalance in the …

Inflammatory response leading to organ dysfunction and failure continues to be the major
problem after injury in many clinical conditions such as sepsis, severe burns, acute …

Multiple organ failure (MOF) has reached epidemic proportions in most intensive care units
and is fast becoming the most common cause of death in the surgical intensive care unit …

Objectives The systemic inflammatory response syndrome (SIRS) is the massive
inflammatory reaction resulting from systemic mediator release that may lead to multiple …

Inflammatory mediators play a key role in acute pancreatitis and the resultant multiple organ
dysfunction syndrome, which is the primary cause of death in this condition. Recent studies …

Objective The effects of interleukin (IL)-6 in the injured patient are examined in an attempt to
clarify the potential pathophysiologic role of IL-6 in the response to injury. Summary …

Background: Major depressive disorder (MDD) is associated with increased risk for
premature coronary heart disease and bone loss. Single time measurements of plasma IL-6 …

Controlling the extent of inflammatory responses following brain injury may be beneficial
since posttraumatic intracranial inflammation has been associated with adverse outcome. In …

The Acute Phase Response During good health, when there are no substantial threats to
body integrity, our homeostatic mechanisms maintain an optimal internal environment in the …

Background The aim of this study is to assess the associations between the timing of
secondary definitive fracture surgery on inflammatory changes and outcome in the patient …