[HTML][HTML] Biocatalysis

EL Bell, W Finnigan, SP France, AP Green… - Nature Reviews …, 2021 - nature.com
Biocatalysis has become an important aspect of modern organic synthesis, both in
academia and across the chemical and pharmaceutical industries. Its success has been …

Metabolic engineering: methodologies and applications

MJ Volk, VG Tran, SI Tan, S Mishra, Z Fatma… - Chemical …, 2022 - ACS Publications
Metabolic engineering aims to improve the production of economically valuable molecules
through the genetic manipulation of microbial metabolism. While the discipline is a little over …

Shortening synthetic routes to small molecule active pharmaceutical ingredients employing biocatalytic methods

S Simić, E Zukić, L Schmermund, K Faber… - Chemical …, 2021 - ACS Publications
Biocatalysis, using enzymes for organic synthesis, has emerged as powerful tool for the
synthesis of active pharmaceutical ingredients (APIs). The first industrial biocatalytic …

From nature to industry: Harnessing enzymes for biocatalysis

R Buller, S Lutz, RJ Kazlauskas, R Snajdrova… - Science, 2023 - science.org
Biocatalysis harnesses enzymes to make valuable products. This green technology is used
in countless applications from bench scale to industrial production and allows practitioners …

Enzyme entrapment, biocatalyst immobilization without covalent attachment

HT Imam, PC Marr, AC Marr - Green Chemistry, 2021 - pubs.rsc.org
In entrapment an active species, which is often a catalyst, is trapped within a material by a
solid or gel forming event; thus, it becomes dispersed within the solid or semi-solid matrix …

Machine learning-enabled retrobiosynthesis of molecules

T Yu, AG Boob, MJ Volk, X Liu, H Cui, H Zhao - Nature Catalysis, 2023 - nature.com
Retrobiosynthesis provides an effective and sustainable approach to producing functional
molecules. The past few decades have witnessed a rapid expansion of biosynthetic …

Biocatalysis as key to sustainable industrial chemistry

AR Alcántara, P Domínguez de María… - …, 2022 - Wiley Online Library
The role and power of biocatalysis in sustainable chemistry has been continuously brought
forward step by step to its present outstanding position. The problem‐solving capabilities of …

Designing microbial cell factories for the production of chemicals

JS Cho, GB Kim, H Eun, CW Moon, SY Lee - Jacs Au, 2022 - ACS Publications
The sustainable production of chemicals from renewable, nonedible biomass has emerged
as an essential alternative to address pressing environmental issues arising from our heavy …

Toward autonomous laboratories: Convergence of artificial intelligence and experimental automation

Y Xie, K Sattari, C Zhang, J Lin - Progress in Materials Science, 2023 - Elsevier
The ever-increasing demand for novel materials with superior properties inspires retrofitting
traditional research paradigms in the era of artificial intelligence and automation. An …

The evolving nature of biocatalysis in pharmaceutical research and development

SP France, RD Lewis, CA Martinez - JACS Au, 2023 - ACS Publications
Biocatalysis is a highly valued enabling technology for pharmaceutical research and
development as it can unlock synthetic routes to complex chiral motifs with unparalleled …