A field guide to foldamers
The breadth of structure and function displayed by the molecules of biology is remarkable.
Considering that there are only three major biopolymer backbones (proteins, ribonucleic …
Considering that there are only three major biopolymer backbones (proteins, ribonucleic …
The protein folding problem
The “protein folding problem” consists of three closely related puzzles:(a) What is the folding
code?(b) What is the folding mechanism?(c) Can we predict the native structure of a protein …
code?(b) What is the folding mechanism?(c) Can we predict the native structure of a protein …
RaptorX-Property: a web server for protein structure property prediction
Abstract RaptorX Property (http://raptorx2. uchicago. edu/StructurePropertyPred/predict/) is a
web server predicting structure property of a protein sequence without using any templates …
web server predicting structure property of a protein sequence without using any templates …
[HTML][HTML] Protein secondary structure prediction using deep convolutional neural fields
Protein secondary structure (SS) prediction is important for studying protein structure and
function. When only the sequence (profile) information is used as input feature, currently the …
function. When only the sequence (profile) information is used as input feature, currently the …
[HTML][HTML] Affibody molecules: engineered proteins for therapeutic, diagnostic and biotechnological applications
J Löfblom, J Feldwisch, V Tolmachev, J Carlsson… - FEBS letters, 2010 - Elsevier
Affibody molecules are a class of engineered affinity proteins with proven potential for
therapeutic, diagnostic and biotechnological applications. Affibody molecules are small (6.5 …
therapeutic, diagnostic and biotechnological applications. Affibody molecules are small (6.5 …
The protein folding 'speed limit'
How fast can a protein possibly fold? This question has stimulated experimentalists to seek
fast folding proteins and to engineer them to fold even faster. Proteins folding at or near the …
fast folding proteins and to engineer them to fold even faster. Proteins folding at or near the …
Detecting biothreat agents: From current diagnostics to developing sensor technologies
SA Walper, G Lasarte Aragonés, KE Sapsford… - ACS …, 2018 - ACS Publications
Although a fundamental understanding of the pathogenicity of most biothreat agents has
been elucidated and available treatments have increased substantially over the past …
been elucidated and available treatments have increased substantially over the past …
Is there a unifying mechanism for protein folding?
Proteins appear to fold by diverse pathways, but variations of a simple mechanism–
nucleation-condensation–describe the overall features of folding of most domains. In …
nucleation-condensation–describe the overall features of folding of most domains. In …
Superantigen recognition and interactions: functions, mechanisms and applications
AM Deacy, SKE Gan, JP Derrick - Frontiers in Immunology, 2021 - frontiersin.org
Superantigens are unconventional antigens which recognise immune receptors outside
their usual recognition sites eg complementary determining regions (CDRs), to elicit a …
their usual recognition sites eg complementary determining regions (CDRs), to elicit a …
Smaller and faster: The 20-residue Trp-cage protein folds in 4 μs
L Qiu, SA Pabit, AE Roitberg… - Journal of the American …, 2002 - ACS Publications
We have used laser temperature jump spectroscopy to measure the folding speed of the 20-
residue Trp-cage, the smallest polypeptide known to exhibit truly cooperative folding …
residue Trp-cage, the smallest polypeptide known to exhibit truly cooperative folding …