Rational design, synthesis and biological screening of triazine-triazolopyrimidine hybrids as multitarget anti-Alzheimer agents
In our endeavor towards the development of potent multitarget ligands for the treatment of
Alzheimer's disease, a series of triazine-triazolopyrimidine hybrids were designed …
Alzheimer's disease, a series of triazine-triazolopyrimidine hybrids were designed …
Proteasome mediated degradation of CDC25C and Cyclin B1 in Demethoxycurcumin treated human glioma U87 MG cells to trigger G2/M cell cycle arrest
Recently, we have reported that Demethoxycurcumin induced Reactive oxygen species via
inhibition of Mitochondrial Superoxide Dismutase is an initial event to trigger apoptosis …
inhibition of Mitochondrial Superoxide Dismutase is an initial event to trigger apoptosis …
Design, synthesis, DNA binding studies and evaluation of anticancer potential of novel substituted biscarbazole derivatives against human glioma U87 MG cell line
In this research paper, we report the design and synthesis of novel substituted biscarbazole
derivatives which were characterized by 1 H and 13 C NMR, high resolution mass …
derivatives which were characterized by 1 H and 13 C NMR, high resolution mass …
Demethoxycurcumin mediated targeting of MnSOD leading to activation of apoptotic pathway and inhibition of Akt/NF-κB survival signalling in human glioma U87 MG …
Earlier, we reported that Demethoxycurcumin (DMC) suppressed the growth of human
glioma U87 MG cells by downregulation of Bcl-2 expression. In the present work, we …
glioma U87 MG cells by downregulation of Bcl-2 expression. In the present work, we …
New amyloid beta-disaggregating agents: synthesis, pharmacological evaluation, crystal structure and molecular docking of N-(4-((7-chloroquinolin-4-yl) oxy)-3 …
In the journey towards the development of potent multi-targeted ligands for the treatment of
Alzheimer's disease, a series of Aβ aggregation inhibitors having quinoline scaffold were …
Alzheimer's disease, a series of Aβ aggregation inhibitors having quinoline scaffold were …
Synthesis of novel 4-methylthiocoumarin and comparison with conventional coumarin derivative as a multi-target-directed ligand in Alzheimer's disease
Alzheimer's disease (AD) is a multifactorial disorder characterized by cognitive deficit and
memory loss. The pathological feature of the disease involves β-amyloid senile plaques …
memory loss. The pathological feature of the disease involves β-amyloid senile plaques …
Synthesis and biological evaluation of quinoline/cinnamic acid hybrids as amyloid-beta aggregation inhibitors
YX Ge, ZQ Cheng, L Zhou, HX Xie, YY Wang… - Monatshefte für Chemie …, 2020 - Springer
The objective of the current study is to evaluate the potency of quinoline/cinnamic acid
hybrids against amyloid-beta (Aβ) aggregation. In total, six new target quinoline/cinnamic …
hybrids against amyloid-beta (Aβ) aggregation. In total, six new target quinoline/cinnamic …