The discovery of regulated cell death presents tantalizing possibilities for gaining control
over the life–death decisions made by cells in disease. Although apoptosis has been the …

The mitochondrial permeability transition (PT) is a permeability increase of the inner
mitochondrial membrane mediated by a channel, the permeability transition pore (PTP) …

A variety of stimuli utilize an increase of cytosolic free Ca2+ concentration as a second
messenger to transmit signals, through Ca2+ release from the endoplasmic reticulum or …

Perinatal hypoxic‐ischemic encephalopathy (HIE) is a significant cause of mortality and
morbidity in infants and young children. Therapeutic opportunities are very limited for …

In autophagy long‐lived proteins, protein aggregates or damaged organelles are engulfed
by vesicles called autophagosomes prior to lysosomal degradation. Autophagy dysfunction …

Hypoxic‐ischaemic damage to the developing brain is a leading cause of child death, with
high mortality and morbidity, including cerebral palsy, epilepsy, and cognitive disabilities …

Perinatal insults such as hypoxia–ischemia induces secondary brain injury. In order to
develop the next generation of neuroprotective therapies, we urgently need to understand …

1112 ELROD JW et al. red-sensitive mechanism (now known to be the mitochondrial
calcium uniporter (MCU), the genetic identity of which was recently discovered14–16) and …

Acute neurological conditions such as cerebrovascular diseases and trauma are associated
with irreversible loss of neurons and glial cells. Severe or prolonged injury results in …

Hypoxia-ischemia in the perinatal period is an important cause of cerebral palsy and
associated disabilities in children. Cerebral palsy is one of the most costly neurologic …