C–C bond forming radical SAM enzymes involved in the construction of carbon skeletons of cofactors and natural products
K Yokoyama, EA Lilla - Natural product reports, 2018 - pubs.rsc.org
Covering: up to the end of 2017 C–C bond formations are frequently the key steps in
cofactor and natural product biosynthesis. Historically, C–C bond formations were thought to …
cofactor and natural product biosynthesis. Historically, C–C bond formations were thought to …
Cobalamin-Dependent Radical S-Adenosylmethionine Enzymes: Capitalizing on Old Motifs for New Functions
The members of the radical S-adenosylmethionine (SAM) enzyme superfamily are
responsible for catalyzing a diverse set of reactions in a multitude of biosynthetic pathways …
responsible for catalyzing a diverse set of reactions in a multitude of biosynthetic pathways …
A widespread pathway for substitution of adenine by diaminopurine in phage genomes
Y Zhou, X Xu, Y Wei, Y Cheng, Y Guo, I Khudyakov… - Science, 2021 - science.org
DNA modifications vary in form and function but generally do not alter Watson-Crick base
pairing. Diaminopurine (Z) is an exception because it completely replaces adenine and …
pairing. Diaminopurine (Z) is an exception because it completely replaces adenine and …
AB12-dependent radical SAM enzyme involved in oxetanocin A biosynthesis
Abstract Oxetanocin A (OXT-A) is a potent antitumour, antiviral and antibacterial compound.
Biosynthesis of OXT-A has been linked to a plasmid-borne Bacillus megaterium gene cluster …
Biosynthesis of OXT-A has been linked to a plasmid-borne Bacillus megaterium gene cluster …
How cyanophage S-2L rejects adenine and incorporates 2-aminoadenine to saturate hydrogen bonding in its DNA
Bacteriophages have long been known to use modified bases in their DNA to prevent
cleavage by the host's restriction endonucleases. Among them, cyanophage S-2L is unique …
cleavage by the host's restriction endonucleases. Among them, cyanophage S-2L is unique …
A Rich Man, Poor Man Story of S-Adenosylmethionine and Cobalamin Revisited
J Bridwell-Rabb, TAJ Grell… - Annual Review of …, 2018 - annualreviews.org
S-adenosylmethionine (AdoMet) has been referred to as both “a poor man's
adenosylcobalamin (AdoCbl)” and “a rich man's AdoCbl,” but today, with the ever-increasing …
adenosylcobalamin (AdoCbl)” and “a rich man's AdoCbl,” but today, with the ever-increasing …
The HD-domain metalloprotein superfamily: an apparent common protein scaffold with diverse chemistries
The histidine–aspartate (HD)-domain protein superfamily contains metalloproteins that
share common structural features but catalyze vastly different reactions ranging from …
share common structural features but catalyze vastly different reactions ranging from …
Changing Fates of the Substrate Radicals Generated in the Active Sites of the B12-Dependent Radical SAM Enzymes OxsB and AlsB
OxsB is a B12-dependent radical SAM enzyme that catalyzes the oxidative ring contraction
of 2′-deoxyadenosine 5′-phosphate to the dehydrogenated, oxetane containing …
of 2′-deoxyadenosine 5′-phosphate to the dehydrogenated, oxetane containing …
Cobalamin-dependent radical S-adenosyl-l-methionine enzymes in natural product biosynthesis
SC Wang - Natural product reports, 2018 - pubs.rsc.org
Covering: 2011 to 2018 This highlight summarizes the investigation of cobalamin (Cbl)-and
radical S-adenosyl-L-methionine (SAM)-dependent enzymes found in natural product …
radical S-adenosyl-L-methionine (SAM)-dependent enzymes found in natural product …
Cryptic phosphorylation in nucleoside natural product biosynthesis
Kinases are annotated in many nucleoside biosynthetic gene clusters but generally are
considered responsible only for self-resistance. Here, we report an unexpected 2 …
considered responsible only for self-resistance. Here, we report an unexpected 2 …