The discovery in 2006 that loss-of-function mutations in the filaggrin gene (FLG) cause
ichthyosis vulgaris and can predispose to atopic dermatitis (AD) galvanized the dermatology …

Atopic dermatitis (AD) is the most common inflammatory skin disease worldwide, affecting
20% of children and 5% of adults. One critical component in the pathophysiology of AD is …

Background Atopic dermatitis (AD) is driven by the interplay between a dysfunctional
epidermal barrier and a skewed cutaneous immune dysregulation. As part of the complex …

Epidermal barrier integrity could be influenced by various factors involved in epidermal cell
differentiation and proliferation, cell–cell adhesion, and skin lipids. Dysfunction of this barrier …

The marine environment represents an underexploited resource for the discovery of novel
products, despite its high level of biological and chemical diversity. With increasing …

Skin appearance is essential for self‐esteem and quality of life; consequently, skin care
products represent a huge market. In particular, cosmeceuticals constitute a hybrid category …

Chronic itch in the elderly is a common problem, with a significant impact on quality of life
and sleep in elderly patients. Chronic itch may be attributable to several causes, including …

Human skin is the largest organ of the body and is an effective physical barrier keeping it
from environmental conditions. This barrier function of the skin is based on stratum corneum …

Rosacea is a common chronic inflammation of sebaceous gland–rich facial skin
characterized by severe skin dryness, elevated pH, transepidermal water loss, and …

The stratum corneum of the epidermis is composed of stacked dead corneocytes embedded
in lipid layers and is the main protective shield of the skin. The thickness of the stratum …