Protein handling, modification and folding in the endoplasmic reticulum (ER) are tightly
regulated processes that determine cell function, fate and survival. In several tumour types …

To survive, cancer cells must resist numerous internal and environmental insults associated
with neoplasia that jeopardize proteostasis within the endoplasmic reticulum (ER). Solid and …

The c-Myc oncogene drives malignant progression and induces robust anabolic and
proliferative programmes leading to intrinsic stress. The mechanisms enabling adaptation to …

Cancer constitutes a grave problem nowadays in view of the fact that it has become one of
the main causes of death worldwide. Poor clinical prognosis is presumably due to cancer …

The proposed molecular mechanisms underlying neurodegenerative pathogenesis are
varied, precluding the development of effective therapies for these increasingly prevalent …

Circadian rhythms are natural rhythms that widely exist in all creatures, and regulate the
processes and physiological functions of various biochemical reactions. The circadian clock …

Cutaneous malignant melanoma is an aggressive cancer of melanocytes with a strong
propensity to metastasize. We posit that melanoma cells acquire metastatic capability by …

The unfolded protein response (UPR) is an evolutionarily conserved stress response to intra-
and extracellular conditions that disrupt endoplasmic reticulum (ER) protein-folding capacity …

The unfolded protein response (UPR) is a stress-activated signalling pathway that regulates
cell proliferation, metabolism and survival. The circadian clock coordinates metabolism and …

To maintain proteostasis, cells must integrate information and activities that supervise
protein synthesis, protein folding, conformational stability, and also protein degradation …