Diagnostic, prognostic, and therapeutic value of droplet digital PCR (ddPCR) in COVID-19 patients: a systematic review

A Ishak, MM AlRawashdeh, SM Esagian… - Journal of clinical …, 2021 - mdpi.com
Accurate detection of SARS-CoV-2, the pathogen causing the global pandemic of COVID-
19, is essential for disease surveillance and control. Quantitative reverse transcription PCR …

Therapeutic implications of ongoing alveolar viral replication in COVID-19

D McGonagle, MF Kearney, A O'Regan… - The Lancet …, 2022 - thelancet.com
In patients with moderate-to-severe COVID-19 pneumonia, an aberrant post-viral alveolitis
with excessive inflammatory responses and immunothrombosis underpins use of …

Neuroinvasion and neurotropism by SARS-CoV-2 variants in the K18-hACE2 mouse

F Seehusen, JJ Clark, P Sharma, EG Bentley, A Kirby… - Viruses, 2022 - mdpi.com
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) not only affects the
respiratory tract but also causes neurological symptoms such as loss of smell and taste …

[HTML][HTML] Duration of SARS-CoV-2 viremia and its correlation to mortality and inflammatory parameters in patients hospitalized for COVID-19: a cohort study

K Hagman, M Hedenstierna, J Rudling… - … and infectious disease, 2022 - Elsevier
SARS-CoV-2 viremia at admission is associated with high risk for mortality. However,
longitudinal data on viremia duration are limited. Viremic patients hospitalized for COVID-19 …

COVID-19 biomarkers at the crossroad between patient stratification and targeted therapy: the role of validated and proposed parameters

M Rizzi, D D'Onghia, S Tonello, R Minisini… - International Journal of …, 2023 - mdpi.com
Clinical knowledge about SARS-CoV-2 infection mechanisms and COVID-19
pathophysiology have enormously increased during the pandemic. Nevertheless, because …

SARS‐CoV‐2 in digital era: Diagnostic techniques and importance of nucleic acid quantification with digital PCRs

N Aravind Kumar, S Aradhana, Harleen… - Reviews in Medical …, 2023 - Wiley Online Library
Studies related to clinical diagnosis and research of SARS‐CoV‐2 are important in the
current pandemic era. Although molecular biology has emphasised the importance of …

Prevalence and clinical relevance of viraemia in viral respiratory tract infections: a systematic review

K Hagman, T Postigo, D Diez-Castro, J Ursing… - The Lancet …, 2024 - thelancet.com
In this Review, we analysed the prevalence of viraemia during infection with SARS-CoV-2
and other relevant respiratory viruses, including other human coronaviruses such as MERS …

Relevant SARS‐CoV‐2 viremia is associated with COVID‐19 severity: Prospective cohort study and validation cohort

L Cardeñoso Domingo, E Roy Vallejo… - Journal of Medical …, 2022 - Wiley Online Library
Early kinetics of SARS‐CoV‐2 viral load (VL) in plasma determined by quantitative reverse‐
transcription polymerase chain reaction (RT‐PCR) was evaluated as a predictor of poor …

SARS-CoV-2 blood RNA load predicts outcome in critically ill COVID-19 patients

F Heinrich, MF Nentwich… - Open forum …, 2021 - academic.oup.com
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA loads in
patient specimens may act as a clinical outcome predictor in critically ill patients with …

Correlation of SARS-CoV-2 nasopharyngeal CT values with viremia and mortality in adults hospitalized with COVID-19

K Hagman, M Hedenstierna, J Widaeus… - Open Forum …, 2022 - academic.oup.com
Background Both severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viremia
and nasopharyngeal viral load have been suggested to be predictors of unfavorable …