Hypothalamic kisspeptin neurons serve as the nodal regulatory centre of reproductive
function. These neurons are subjected to a plethora of regulatory factors that ultimately affect …

The bioactive peptides galanin, spexin and kisspeptin have a common ancestral origin and
their pathophysiological roles are increasingly the subject of investigation. Evidence …

Endometriosis and polycystic ovary syndrome (PCOS) are two common female reproductive
disorders with a significant impact on the health and quality of life of women affected. A …

The etiology of central precocious puberty (CPP) is multiple and heterogeneous, including
congenital and acquired causes that can be associated with structural or functional brain …

Background: Adequate dietary intake and nutritional status have important effects on brain
functions and on brain health. Energy intake and specific nutrients excess or deficiency from …

Ovulatory disorders are the most common clinical feature exhibited among obese women.
Initiation of ovulation physiologically requires a surge of gonadotropin-releasing hormone …

Albeit essential for perpetuation of species, reproduction is an energy-demanding function
that can be adjusted to body metabolic status. Reproductive maturation and function can be …

Kisspeptin has recently emerged as a key regulator of the mammalian reproductive axis. It is
known that kisspeptin, acting centrally via the kisspeptin receptor, stimulates secretion of …

In late 2003, a major breakthrough in our understanding of the mechanisms that govern
reproduction occurred with the identification of the reproductive roles of kisspeptins …

Neurons in the hypothalamic arcuate nucleus (ARC) that co-express kisspeptin, neurokinin
B and dynorphin (KNDy cells) are essential for mammalian reproduction as key regulators of …