Mitochondria, the main provider of energy in eukaryotic cells, contains more than 1000
different proteins and is closely related to the development of cells. However, damaged …

Mitochondrial ClpP is a serine protease located in the mitochondrial matrix. This protease
participates in mitochondrial protein quality control by degrading misfolded or damaged …

The mitochondrial caseinolytic protease P (ClpP) plays a central role in mitochondrial
protein quality control by degrading misfolded proteins. Using genetic and chemical …

ONC201 is a first-in-class imipridone molecule currently in clinical trials for the treatment of
multiple cancers. Despite enormous clinical potential, the mechanism of action is …

Chemo-activation of mitochondrial ClpP exhibits promising anticancer properties. However,
we are currently unaware of any studies using selective and potent ClpP activators in lung …

The ClpXP degradation machine consists of a hexameric AAA+ unfoldase (ClpX) and a pair
of heptameric serine protease rings (ClpP) that unfold, translocate, and subsequently …

Mitochondria play a key role in cancer and their involvement is not limited to the production
of ATP only. Mitochondria also produce reactive oxygen species and building blocks to …

ClpP is a highly conserved serine protease that is a critical enzyme in maintaining protein
homeostasis and is an important drug target in pathogenic bacteria and various cancers. In …

The emergence of methicillin-resistant Staphylococcus aureus isolates highlights the urgent
need to develop more antibiotics. ClpP is a highly conserved protease regulated by …

The mitochondrial caseinolytic protease P (ClpP) is a target candidate for treating leukemia;
however, the effects of ClpP modulation on solid tumors have not been adequately explored …