Fluoroorganic chemistry has become essential in the evolution of many different but
interconnected research fields. These include the development of new materials with a …

The role of fluorine in drug design and development is expanding rapidly as we learn more
about the unique properties associated with this unusual element and how to deploy it with …

The proline-specific dipeptidyl aminopeptidase IV (DPP IV, DPP-4, CD26), widely expressed
in mammalians, releases X-Pro/Ala dipeptides from the N-terminus of peptides. DPP IV is …

In our effort to discover DPP-4 inhibitors with added benefits over currently commercially
available DPP-4 inhibitors, MK-3102 (omarigliptin), was identified as a potent and selective …

Emerging as an epidemic of the 21st century type 2 diabetes has become a major health
problem throughout the globe. The number of deaths attributable to diabetes reflects the …

DPP-4 (dipeptidyl peptidase-4) degrades the incretin hormones GLP-1 (glucagon-like
peptide-1) and GIP (gastric inhibitory polypeptide), decreasing their stimulatory effects on β …

Abstract Type 2 Diabetes Mellitus (T2DM) is one of the highly prevalence disorder and
increasing day by day worldwidely. T2DM is a metabolic disorder, which is characterized by …

Abstract Dipeptidyl peptidase-4 (DPP-4) is one of the widely explored novel targets for Type
2 diabetes mellitus (T2DM) currently. Research has been focused on the strategy to …

Dipeptidyl peptidase IV (DPP IV) is a key regulator of insulin-stimulating hormones,
glucagon-like peptide (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), thus …

Diabetes represents a major health problem, involving a severe imbalance of blood sugar
levels, which can disturb the nerves, eyes, kidneys, and other organs. Diabes management …