Cachexia is a devastating, multifactorial and often irreversible systemic syndrome
characterized by substantial weight loss (mainly of skeletal muscle and adipose tissue) that …

Elevated mitochondrial matrix superoxide and/or hydrogen peroxide concentrations drive a
wide range of physiological responses and pathologies. Concentrations of superoxide and …

Background: Anterior cruciate ligament (ACL) injuries and reconstruction (ACLR) promote
quadriceps muscle atrophy and weakness that can persist for years, suggesting the need for …

Background As the effectiveness of breast cancer treatment has improved, a growing
number of long-term breast cancer survivors are seeking help for unique health problems …

Redox changes and generation of reactive oxygen species (ROS) are part of normal cell
metabolism. While low ROS levels are implicated in cellular signaling pathways necessary …

Although denervated muscle atrophy is common, the underlying molecular mechanism
remains unelucidated. We have previously found that oxidative stress and inflammatory …

Breast cancer represents the most commonly diagnosed cancer while neoadjuvant and
adjuvant chemotherapies are extensively used in order to reduce tumor development and …

Background Chemotherapy is extensively used to treat breast cancer and is associated with
skeletal muscle deconditioning, which is known to reduce patients' quality of life, treatment …

Denervated muscle atrophy is a common clinical disease that has no effective treatments.
Our previous studies have found that oxidative stress and inflammation play an important …

Cancer cachexia is a debilitating syndrome characterized by skeletal muscle wasting,
weakness and fatigue. Several pathogenetic mechanisms can contribute to these muscle …