Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by a failure of
spontaneous resolution of inflammation. Although the pro-inflammatory cytokines and …

Summary Interleukin‐33 (IL‐33) is a tissue‐derived nuclear cytokine from the IL‐1 family
abundantly expressed in endothelial cells, epithelial cells and fibroblast‐like cells, both …

Abstract Interleukin-33 (IL-33)—a member of the IL-1 family—was originally described as an
inducer of type 2 immune responses, activating T helper 2 (TH2) cells and mast cells. Now …

Rheumatoid arthritis is an autoimmune disease that exhibits significant clinical
heterogeneity. There are various treatments for rheumatoid arthritis, including disease …

Rheumatoid arthritis (RA), an autoimmune disease that affects∼ 1% of the human
population, is driven by autoantibodies that target modified self-epitopes, whereas∼ 11% of …

Our immune system is based on the close collaboration of the innate and adaptive immune
systems for the rapid detection of any threats to the host. Recognition of pathogen-derived …

Rheumatoid arthritis (RA) is a chronic, inflammatory autoimmune disease of unknown
etiology. It is characterized by the presence of rheumatoid factor and anti-citrullinated …

Targeted inhibition of cytokine pathways provides opportunities to understand fundamental
biology in vivo in humans. The IL-33 pathway has been implicated in the pathogenesis of …

Abstract Interleukin 33 (IL-33) is a member of the IL-1 family of cytokines with a growing
number of target cells and a plethora of biological functions. Although it has commonalities …

Alzheimer's disease (AD) is a devastating condition with no known effective treatment. AD is
characterized by memory loss as well as impaired locomotor ability, reasoning, and …