Genomic instability in disease and its fidelity in health depend on the DNA damage
response (DDR), regulated in part from the complex of meiotic recombination 11 homolog 1 …

Genome instability is a hallmark of cancer cells and can be accelerated by defects in cellular
responses to DNA damage. This feature of malignant cells opens new avenues for tumor …

The licensing of talimogene laherparepvec (T-Vec) represented a landmark moment for
oncolytic virotherapy, since it provided unequivocal evidence for the long-touted potential of …

Abstract Hexavelant chromium (Cr (V1)) is a widely distributed environmental pollutant
inducing damage in different organs of human and animals. The current study was designed …

Oncolytic viruses selectively target and kill cancer cells in an immunogenic fashion, thus
supporting the establishment of therapeutically relevant tumor-specific immune responses …

Claspin was discovered as a Chk1‐interacting protein necessary for Chk1 phosphorylation
and activation by the upstream kinase, ATR, in response to DNA synthesis inhibition in …

Virotherpay is emerging as a promising strategy against cancer, and three oncolytic viruses
(OVs) have gained approval in different countries for the treatment of several cancer types …

A growing body of evidence suggests that a subset of cells within tumors are resistant to
conventional treatment modalities and may be responsible for disease recurrence. These …

Abstract The simian virus 40 (SV40) replisome only encodes for its helicase; large T-antigen
(L-Tag), while relying on the host for the remaining proteins, making it an intriguing model …

Metastatic pancreatic ductal adenocarcinomas (PDAC) are incurable due to the rapid
development of resistance to all current therapeutics. Oncolytic adenoviral mutants have …